Optical Analysis of Acute Changes after Peripheral Nerve Injury in Spatio-Temporal Pattern of Neural Response to Forelimb Stimulation in Rat Somatosensory Cortex
Optical Analysis of Acute Changes after Peripheral Nerve Injury in Spatio-Temporal Pattern of Neural Response to Forelimb Stimulation in Rat Somatosensory Cortex
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DOI：
10.1016/j.neuroscience.2020.09.020
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发表时间：
2020-11-10
期刊：
影响因子：
3.3
通讯作者：
Hirota，Akihiko
中科院分区：
文献类型：
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作者：
Hama，Noriyuki;Kawai，Minako;Hirota，Akihiko
周围神经损伤导致中枢神经系统功能重组。这种重组背后的机制已经得到了广泛的研究。我们以前的研究涉及多点光学记录，报道了由躯体刺激引起的神经兴奋波开始于一个小区域，并在大脑皮层传播。在本研究中，我们分析了神经损伤后即刻和30 分钟感觉诱发波的时空模式的早期变化，以探讨这种传播波在皮层重组中的可能作用。尺神经或正中神经损伤后，由尺神经支配并毗邻正中神经区的小鱼际刺激反应持续存在。最初，我们评估了焦点反应模式的变化。尺神经损伤后潜伏期延长，正中神经损伤后潜伏期无明显变化。同样，两种神经损伤的反应信号的持续时间都没有变化。其次，分析了传播波型的变化。尺神经损伤降低了正中方向的传播速度，而正中神经损伤对其无影响。这些结果表明，传播波的模式很容易改变，甚至在神经损伤后立即改变，并提示这种时空模式的即时改变是促成皮质重组的因素之一。
Peripheral nerve injury induces functional reorganization of the central nervous system. The mechanisms underlying this reorganization have been widely studied. Our previous study involving multiple-site optical recording reported that a neural excitatory wave induced by somatic stimulation begins in a small area and propagates in the cortex. In the present study, to examine the possible role of this propagation wave in cortical reorganization, we analyzed the early changes in the spatio-temporal pattern of the sensory-evoked wave immediately, and 30 min, after nerve injury. The response to hypothenar stimulation, innervated by the ulnar nerve and adjoining the median nerve area, persisted after injury to either the ulnar or median nerve. Initially, we assessed changes in the response pattern at the focus. The latency increased after ulnar nerve injury, whereas no change was observed after median nerve injury. Similarly, no change was noted in the duration of the response signal with either nerve injury. Second, changes in the propagation wave pattern were analyzed. Ulnar nerve injury decreased the propagation velocity in the medial direction but the median nerve injury induced no changes. These results indicated that the propagation wave pattern is readily altered, even immediately after nerve injury, and suggest that this immediate change in the spatio-temporal pattern is one of the factors contributing to the cortical reorganization.