High-level expression of CD109 is frequently detected in lung squamous cell carcinomas
High-level expression of CD109 is frequently detected in lung squamous cell carcinomas
复制标题
DOI：
10.1111/j.1440-1827.2007.02168.x
复制
发表时间：
2007-11-01
影响因子：
2.2
通讯作者：
Takahashi, Masahide
中科院分区：
文献类型：
--
作者：
Sato, Tomoko;Murakumo, Yoshiki;Takahashi, Masahide
CD 109是糖基磷脂酰肌醇（GPI）锚定的细胞表面蛋白，是α 2-巨球蛋白/含硫酯蛋白的C3、C4、C5家族的成员。据报道，CD 109在造血细胞、内皮细胞和多种人类肿瘤中表达。本文报道了与包括腺癌、大细胞癌和小细胞癌的其它类型的肺癌相比，CD 109蛋白优先在肺鳞状细胞癌中表达。使用抗CD 109抗体的手术切除的肺标本的免疫组织化学染色检测到CD 109表达的支气管和细支气管上皮细胞和肌上皮细胞的支气管分泌腺，但不是在支气管和细支气管顶端上皮细胞和肺泡上皮细胞。此外，与其他类型的肺癌相比，在鳞状细胞癌中观察到CD 109免疫反应性的频率很高。尽管CD 109蛋白的详细功能尚不清楚，但这些结果表明CD 109表达可能在肺鳞状细胞癌的发生中发挥作用。
CD109 is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein, which is a member of the alpha 2-macroglobulin/C3, C4, C5 family of thioester-containing proteins. It has been reported that CD109 is expressed in a subset of hematopoietic cells, endothelial cells and several kinds of human tumors. Herein it is reported that the CD109 protein is preferentially expressed in lung squamous cell carcinomas compared with other types of lung carcinoma including adenocarcinomas, large cell carcinomas and small cell carcinomas. Immunohistochemical staining of surgically resected lung specimens using an anti-CD109 antibody detected CD109 expression in basal cells of bronchial and bronchiolar epithelia and myoepithelial cells of bronchial secretary glands, but not in bronchial and bronchiolar apical epithelial cells and alveolar epithelial cells. Furthermore, the CD109 immunoreactivity was observed in squamous cell carcinomas at a high frequency compared with other types of lung carcinoma. Although the detailed function of CD109 protein is unclear, these results suggest that CD109 expression may play a role in the development of lung squamous cell carcinoma.