Oral colonization by Candida species in AIDS pediatric patients
Oral colonization by Candida species in AIDS pediatric patients
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DOI：
10.1111/j.1601-0825.2010.01765.x
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发表时间：
2011-05-01
期刊：
影响因子：
3.8
通讯作者：
Antunes, J. L. F.
中科院分区：
文献类型：
--
作者：
Domaneschi, C.;Massarente, D. B.;Antunes, J. L. F.
本研究的目的是评估念珠菌口腔定植相关因素的患病率。儿童艾滋病患者样本包括117名儿童。临床状况、使用的药物和实验室检查结果来自医院记录;社会人口学数据由亲属提供。牙科检查评估龋齿的患病率。口腔念珠菌定植率为62%。只有7名儿童出现口腔念珠菌病的临床表现，尽管他们的病毒载量指数高，低年龄的CD 4计数。念珠菌定植与频繁使用抗生素（患病率[PR] = 1.44）、磺胺类药物（PR = 1.23）、口腔粘膜改变（PR = 1.55）和未经治疗的龋齿（PR = 1.93）直接相关。它与抗逆转录病毒治疗的使用呈负相关（PR = 0.65）。白色念珠菌是最常检出的菌种（80%）;表型试验未检出念珠菌。都柏林菌株本研究观察到这些患者中念珠菌相关口腔病变的患病率较低，这与抗逆转录病毒药物可能有助于减少念珠菌感染的口腔表现的假设一致。念珠菌定植在HIV+/AIDS儿童未经治疗的龋齿的高患病率加强了口腔保健的重要性，在跨学科的卫生单位，帮助这些患者。
The aim of this study was to assess the prevalence of factors associated with oral colonization by Candida spp. in pediatric patients with AIDS. The sample comprised of 117 children. Clinical status, medicines in use, and laboratory findings were obtained from hospital records; sociodemographic data were given by relatives. A dental examination assessed the prevalence of dental caries. The prevalence of oral colonization by Candida was 62%. Only seven children presented clinical manifestation of oral candidosis despite their high viral load index and low-for-age CD4 count. Candida colonization was directly associated with frequent use of antibiotics (prevalence ratio [PR] = 1.44), sulfa drugs (PR = 1.23), alteration in the oral mucosa (PR = 1.55), and untreated dental caries (PR = 1.93). It was inversely associated with the use of antiretroviral therapies (PR = 0.65). Candida albicans was the most frequently detected species (80%); phenotypic tests did not detect C. dubliniensis strains. This study observed a low prevalence of Candida-related oral lesions in these patients, which is compatible with the hypothesis that antiretroviral medicines may have contributed to reducing oral manifestations from Candida infection. The high prevalence of Candida colonization in HIV+/AIDS children with untreated dental caries reinforces the importance of oral health care in interdisciplinary health units that assist these patients.