Analysis of proximal X chromosome pairing in early female mouse meiosis
Analysis of proximal X chromosome pairing in early female mouse meiosis
复制标题
雌性小鼠减数分裂早期近端X染色体配对分析
DOI：
10.1007/s004120050248
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发表时间：
1997
期刊：
影响因子：
1.6
通讯作者：
C. Tease
中科院分区：
文献类型：
--
作者：
C. O’Keeffe;M. Hultén;C. Tease
摘要：研究了雌性小鼠减数分裂时同源染色体配对的启动和进展。用重复复制探针70-38进行荧光原位杂交，在胎儿卵母细胞中鉴定出X染色体的近端。从减数分裂前间期到细线期，X着丝粒似乎随机分布在细胞核中。观察表明，X染色体近端没有突触前的联系。配对的X着丝粒数目从合线期中期到合线期晚期显著增加。因此，X染色体的近端是一个普遍较晚的配对区域，在合子中期之前没有明显的关联。所有染色体的着丝粒异染色质在细线期前到粗线期期间可合并成不同数量的簇。这些簇似乎并不直接参与将同系物聚集在一起，因为X着丝粒并不总是定位在同一簇上。
Abstract.The initiation and progression of homologous chromosome pairing at meiosis were investigated in female mice. The proximal end of the X chromosome was identified in fetal oocytes using fluorescence in situ hybridisation with the repeat copy probe 70-38. The X centromeres appeared to be randomly positioned in the nuclei from pre-meiotic interphase to leptotene. The observations indicated no pre-synaptic association for the proximal end of the X chromosome. There was a significant increase in the number of paired X centromeres from mid-zygotene to late zygotene. The proximal end of the X chromosome is therefore a generally late pairing region with no significant association seen before mid-zygotene. The centromeric heterochromatin of all chromosomes could be seen to associate into varying numbers of clusters during pre-leptotene through to pachytene. These clusters do not seem to be directly involved in bringing homologues together, as X centromeres did not consistently localise to the same cluster.
小鼠 X 染色体物理图和重组图的比较。
影响因子：
4.4
作者：
Disteche,CM;McConnell,GK;Grant,SG;Stephenson,DA;Chapman,VM;Gandy,S;Adler,DA
通讯作者：
Adler,DA