Quantifying human calcium absorption using pharmacokinetic methods.
Quantifying human calcium absorption using pharmacokinetic methods.
复制标题
使用药代动力学方法量化人体钙吸收。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
F. Bartter
中科院分区：
文献类型：
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作者：
A. Broadus;M. Domínguez;F. Bartter
用示踪法和药动学方法同时测定了12名男性的钙吸收。这项研究的目的是校准吸收性钙血症的曲线下面积(AUC)，以便将药代动力学数据与示踪剂得出的估计值进行比较或合并。每个受试者在摄入500毫克钙负荷(作为碳酸盐)期间进行了两次研究，一次没有辅料，一次使用阻碍盐溶解的粘合剂，降低了其吸收能力，从而提供了用于校准方法的广泛的吸光度范围。评估了不同的时间段，其中最好的预测是AUC对超过9h的血钙增加(AUC(9))。对于净吸收钙，其关系式为4.358 x AuC(9)+/-0.820。经验回归系数显著，估计值的误差(0.820 mmoL)可接受。
Calcium absorption was measured simultaneously by tracer and pharmacokinetic methods in 12 men. The purpose of the study was to calibrate the area under the curve (AUC) for absorptive calcemia to permit comparison or pooling of pharmacokinetic data with tracer-derived estimates. Each subject was studied twice during intake of 500 mg calcium loads (as the carbonate salt), once without excipients, and once with a binder that impeded dissolution of the salt, reducing its absorbability and thereby providing a broad range of absorption values over which to calibrate the method. Various time periods were evaluated, with the best prediction being given by the AUC for the increment in serum calcium calculated over 9 h (AUC(9)). For net absorbed calcium (mmol) the relationship was given by 4.358 x AUC(9) +/- 0.820. The empirical regression coefficient was significant and the error of the estimate (0.820 mmol) acceptably small.