Risk factors of early proximal gastric carcinoma in Chinese diagnosed using WHO criteria
Risk factors of early proximal gastric carcinoma in Chinese diagnosed using WHO criteria
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DOI：
10.1111/1751-2980.12240
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发表时间：
2015-06-01
影响因子：
3.5
通讯作者：
Zou, Xiao Ping
中科院分区：
文献类型：
--
作者：
Fang, Cheng;Huang, Qin;Zou, Xiao Ping
目的近端胃癌(PGC)的发病率在全球范围内呈上升趋势，但原因不明。方法对379例符合2010年世界卫生组织诊断标准的手术切除的早期胃癌(EGC)患者的高危因素进行分析，通过回顾患者的病历和食道镜/活检结果，并询问患者及其家属的环境毒素暴露史(ETE)、饮食习惯、家族史(FCH)和个人癌症史(PCH)以及生存情况。结果所有EGC患者的早期PGC所占比例均显著增加(P
ObjectiveThe incidence of proximal gastric carcinoma (PGC) is rising worldwide for unknown reasons. Herein we compare the risk factors of early PGC with distal gastric carcinoma (DGC) in patients treated at a single tertiary hospital in China.MethodsRisk factors of 379 consecutive surgically resected early gastric carcinoma (EGC) diagnosed according to the 2010 World Health Organization criteria were studied by reviewing their medical records and esophagogastroduodenoscopy/biopsy findings and interviewing patients and family members for the patients' history of environmental toxin exposure (ETE), dietary habits, family (FCH) and personal cancer history (PCH) and survival. Differences between PGC (n=115), DGC (n=264) and age-matched and gender-matched controls (n=225) were compared.ResultsProportion of early PGC in all EGC patients was increased significantly (P