Going with the Flow: From Circulating Tumor Cells to DNA
Going with the Flow: From Circulating Tumor Cells to DNA
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DOI：
10.1126/scitranslmed.3006305
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发表时间：
2013-10-16
影响因子：
17.1
通讯作者：
Reis-Filho, Jorge S.
中科院分区：
文献类型：
--
作者：
Bidard, Francois-Clement;Weigelt, Britta;Reis-Filho, Jorge S.
对癌症患者血浆中循环肿瘤DNA（ctDNA）的分子分析有可能提供微创诊断和疾病监测生物标志物。通过将循环肿瘤细胞检测转化为临床试验获得的经验，我们讨论了ctDNA作为生物标志物开发的肿瘤材料来源。
Molecular analyses of circulating tumor DNA (ctDNA) in plasma from cancer patients have the potential to deliver minimally invasive diagnostic and disease-monitoring biomarkers. Drawing from experience gained through the translation of circulating-tumor cell detection to clinical tests, we discuss ctDNA as a source of tumor material for biomarker development.