The MHC locus and genetic susceptibility to autoimmune and infectious diseases.
The MHC locus and genetic susceptibility to autoimmune and infectious diseases.
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DOI：
10.1186/s13059-017-1207-1
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发表时间：
2017-04-27
期刊：
影响因子：
12.3
通讯作者：
Zhernakova A
中科院分区：
文献类型：
--
作者：
Matzaraki V;Kumar V;Wijmenga C;Zhernakova A
在过去的50年中，主要组织相容性复合体（MHC）基因座（也称为人类白细胞抗原（HLA））的变异已被报道为复杂疾病的主要风险因素。最近的进展，包括大的遗传筛查，插补和非加性和上位性效应的分析，有助于更好地了解MHC变异体在不同疾病中的共同和特定作用。我们回顾这些进展，并讨论MHC变异体参与自身免疫性疾病和感染性疾病之间的关系。在这一领域的进一步工作将有助于区分病原体在自身免疫性疾病发展中的作用的替代假设。本文的在线版本（doi：10.1186/s13059-017-1207-1）包含补充材料，可供授权用户使用。
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases. Recent advances, including large genetic screens, imputation, and analyses of non-additive and epistatic effects, have contributed to a better understanding of the shared and specific roles of MHC variants in different diseases. We review these advances and discuss the relationships between MHC variants involved in autoimmune and infectious diseases. Further work in this area will help to distinguish between alternative hypotheses for the role of pathogens in autoimmune disease development. The online version of this article (doi:10.1186/s13059-017-1207-1) contains supplementary material, which is available to authorized users.