Phospholipases A2: Variations on a structural theme and their implications as to mechanism

Phospholipases A2: Variations on a structural theme and their implications as to mechanism
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磷脂酶 A2:结构主题的变化及其对机制的影响

DOI:
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发表时间:
1987
期刊:
影响因子:
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通讯作者:
R. Heinrikson
R. Heinrikson
中科院分区:
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文献类型:
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作者:
J. Maraganore;R. Poorman;R. Heinrikson

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我们研究磷脂酶A2的结构-功能关系的方法是基于这样的假设,即这些酶通过不同的进化过程相关。因此,这种表现出结构和功能变化的酶的特征必须与最终与机制有关的共同主题相一致。我们目前交流的重点是关于蜂毒酶和一种新的磷脂酶A2的研究,这种磷脂酶A2的独特之处在于在49位用赖氨酸取代了天冬氨酸。
Our approach to a study of structure-function relationships in phospholipases A2 is based upon the hypothesis that these enzymes are related by divergent evolutionary processes. Accordingly, characterization of such enzymes, which exhibit structural and functional variations, must be reconciled with a common theme that ultimately relates to mechanism. Our focus in the present communication concerns studies on the bee venom enzyme and a new class of phospholipases A2 that is unique in having a lysine in place of the aspartic acid at position 49.
DOI: --
发表时间: 1985
期刊: The Journal of biological chemistry
影响因子: --
作者:
Renetseder,R;Brunie,S;Dijkstra,BW;Drenth,J;Sigler,PB
通讯作者: Sigler,PB
一类新的磷脂酶 A2,用赖氨酸代替天冬氨酸 49。钙和底物结合的功能后果。
DOI: --
发表时间: 1984
期刊: The Journal of biological chemistry
影响因子: --
作者:
Maraganore,JM;Merutka,G;Cho,W;Welches,W;Kézdy,FJ;Heinrikson,RL
通讯作者: Heinrikson,RL
DOI: --
发表时间: 1982
期刊: The Journal of biological chemistry
影响因子: --
作者:
Randolph,A;Heinrikson,RL
通讯作者: Heinrikson,RL