Expression of GOLM1 Correlates with Prognosis in Human Hepatocellular Carcinoma
Expression of GOLM1 Correlates with Prognosis in Human Hepatocellular Carcinoma
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DOI：
10.1245/s10434-013-3101-8
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发表时间：
2013-12-01
影响因子：
3.7
通讯作者：
Chau, Gar-Yang
中科院分区：
文献类型：
--
作者：
Chen, Ming-Huang;Jan, Yi-Hua;Chau, Gar-Yang
背景血清高尔基体膜蛋白1（GOLM 1）是一种新的肝细胞癌（HCC）生物标志物。然而，很少有研究探讨GOLM 1蛋白表达与肝癌患者的临床病理特征之间的关系。本研究旨在探讨GOLM 1在人肝癌组织中的表达及其与临床病理参数的关系。临床病理资料是通过对1990年至2006年间在台北荣民总医院接受手术切除的193例HCC患者的病历进行详细的回顾性分析获得的。另外120个HCC组织样本由台湾肝癌网络提供作为验证队列。采用免疫组化染色法检测GOLM 1在福尔马林固定、石蜡包埋的组织标本中的表达。GOLM 1在肝癌组织中的表达明显高于相应的正常肝组织（p < 0.01）。中位随访51个月后，多因素分析显示门静脉侵犯（风险比[HR]，1.515; 95%置信区间[95% CI]，1.008-2.277; p = 0.046）和GOLM 1蛋白高表达（HR，1.696; 95% CI，1.160-2.479; p = 0.006）是总生存期较差的独立预后因素。GOLM 1蛋白高表达与总生存率和无病生存率显著相关（p < 0.001和p = 0.002）。GOLM 1过表达与人肝癌预后不良相关
Background. Serum Golgi membrane protein 1 (GOLM1) is a novel biomarker for hepatocellular carcinoma (HCC). However, few studies have investigated the relationship between GOLM1 protein expression and clinicopathologic features in HCC patients. The aim of this study was to investigate the expression of GOLM1 in human HCC and its correlation with clinicopathologic parameters.Methods. Clinicopathologic data were obtained through a detailed retrospective review of the medical records of 193 patients with HCC who had undergone surgical resection between 1990 and 2006 at the Taipei Veterans General Hospital. Another 120 HCC tissue samples provided by the Taiwan Liver Cancer Network were used as validation cohort. Immunohistochemical staining was used to determine the expression of GOLM1 in archived formalin-fixed, paraffin-embedded tissue specimens.Results. GOLM1 expression was significantly higher in resected HCC tumor tissues than in corresponding normal liver tissues (p < 0.01). After a median follow-up of 51 months, multivariate analysis showed that portal vein invasion (hazard ratio [HR], 1.515; 95 % confidence interval [95 % CI], 1.008-2.277; p = 0.046) and high GOLM1 protein expression (HR, 1.696; 95 % CI, 1.160-2.479; p = 0.006) were independent prognostic factors for poor overall survival. High GOLM1 protein expression still significantly correlates with worse overall survival as well as disease-free survival in the validation cohort (p < 0.001 and p = 0.002).Conclusions. Overexpression of GOLM1 is associated with poor prognosis in human HCC.