ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling
ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling
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ERK1 表明良好的预后并通过抑制 YAP1 信号传导抑制乳腺癌进展
DOI：
10.18632/aging.102572
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发表时间：
2019-12
期刊：
影响因子：
5.2
通讯作者：
Liu Yan
中科院分区：
文献类型：
--
作者：
Yu Shiyi;Zhang Meng;Huang Ling;Ma Zhifang;Gong Xue;Liu Weiguang;Zhang Jun;Chen Liming;Yu Zhenghong;Zhao Weiyong;Liu Yan
The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is a well-characterized signaling pathway during the development of various cancer types. ERK1 and ERK2, the two kinase effectors of MAPK cascade, exhibit high similarity. However, it is still unknown whether these two kinases are functionally different or in contrast functionally redundant during the development of breast cancer. We found that ERK1 expression levels were significantly lower in basal breast cancer compared with luminal breast cancer and normal breast tissues. RNA sequencing data suggested that ERK1 was associated with Hippo signaling pathway and cell proliferation in breast cancer cells. The gene set enrichment analysis (GSEA) further showed enrichment for YAP1 signaling pathway in breast cancer cell lines and tumors with low expression of ERK1. Silencing of ERK1 elevated YAP1 expression and TEAD activity in breast cancer cells. Additionally, ERK1 inhibited breast cancer cell proliferation via regulation of YAP1. The Kaplan-Meier analysis of data in patients with breast cancer suggested that, higher expression of ERK1 was associated with better prognosis, whereas, higher expression of ERK2 predicted poorer prognosis. These findings unveiled the role of ERK1 on regulation of YAP1 signaling pathway, indicating ERK1 as a negative regulator of breast cancer progression.
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影响因子：
10.5
作者：
Meng Z;Moroishi T;Guan KL
通讯作者：
Guan KL
影响因子：
8.3
作者：
Lei Q;Tan J;Yi S;Wu N;Wang Y;Wu H
通讯作者：
Wu H
Yes 相关蛋白的敲低通过 Erk 和 Bcl-2 信号通路之间的串扰诱导细胞凋亡，同时抑制人牙周膜干细胞的增殖
影响因子：
3.6
作者：
Wen Y;Ji Y;Zhang Y;Jiang B;Tang C;Wang Q;Chen X;Jia L;Gu W;Xu X
通讯作者：
Xu X
DOI：
10.1016/j.bbagrm.2018.10.005
发表时间：
2018-11
期刊：
Biochimica et biophysica acta. Gene regulatory mechanisms
影响因子：
--
作者：
Melhuish TA;Kowalczyk I;Manukyan A;Zhang Y;Shah A;Abounader R;Wotton D
通讯作者：
Wotton D
影响因子：
37.3
作者：
Peng WX;Huang JG;Yang L;Gong AH;Mo YY
通讯作者：
Mo YY