Induced Pluripotency and Epigenetic Reprogramming
Induced Pluripotency and Epigenetic Reprogramming
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DOI：
10.1101/cshperspect.a019448
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发表时间：
2015-12-01
影响因子：
7.2
通讯作者：
Jaenisch, Rudolf
中科院分区：
文献类型：
--
作者：
Hochedlinger, Konrad;Jaenisch, Rudolf
诱导多能性定义了体细胞在一小组转录因子过表达时转化为诱导多能干细胞（iPSC）的过程。在这篇文章中，我们将转录因子诱导的多能性置于历史背景下，回顾当前生成iPSCs的方法，并讨论重新编程过程中获得的机制见解。此外，我们专注于诱导多能性和新兴技术的潜在治疗应用，以有效地工程化人类多能细胞的基因组用于科学和治疗目的。
Induced pluripotency defines the process by which somatic cells are converted into induced pluripotent stem cells (iPSCs) upon overexpression of a small set of transcription factors. In this article, we put transcription factor-induced pluripotency into a historical context, review current methods to generate iPSCs, and discuss mechanistic insights that have been gained into the process of reprogramming. In addition, we focus on potential therapeutic applications of induced pluripotency and emerging technologies to efficiently engineer the genomes of human pluripotent cells for scientific and therapeutic purposes.