Adaptation-induced synchronization in laminar cortical circuits
Adaptation-induced synchronization in laminar cortical circuits
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DOI：
10.1073/pnas.1102017108
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发表时间：
2011-06-28
影响因子：
11.1
通讯作者：
Dragoi, Valentin
中科院分区：
文献类型：
--
作者：
Hansen, Bryan J.;Dragoi, Valentin
新皮层信息处理的一个基本特征是单个神经元适应传入刺激变化的能力。越来越多的人认识到，皮层适应是一种需要网络相互作用的现象。局部网络的结构严重依赖于皮质层，这一事实提出了一种可能性，即适应可能在不同的层中引起特定的影响。本研究表明，短暂暴露于固定方向的刺激（300 ms）可调节猕猴初级视觉皮层(V1) γ波段频率（30-80 Hz）内单个神经元与局部群体活动之间的同步强度，并影响单个神经元编码刺激方向的能力。利用层流探针，我们发现，尽管刺激呈现引起V1输入层（颗粒层）节律性神经元活动的伽马同步性大幅增加，但适应性导致皮层输出层（核上层）的同步性显著增加。适应后伽马同步的增加仅在核上层与神经元定向识别性能的改善显著相关。因此，单个神经元的峰值活动与其局部群体之间的同步可能会增强感觉编码，从而优化层流电路中的网络处理。
A fundamental feature of information processing in neocortex is the ability of individual neurons to adapt to changes in incoming stimuli. It is increasingly being understood that cortical adaptation is a phenomenon that requires network interactions. The fact that the structure of local networks depends critically on cortical layer raises the possibility that adaptation could induce specific effects in different layers. Here we show that brief exposure (300 ms) to a stimulus of fixed orientation modulates the strength of synchronization between individual neurons and local population activity in the gamma-band frequency (30-80 Hz) in macaque primary visual cortex (V1) and influences the ability of individual neurons to encode stimulus orientation. Using laminar probes, we found that although stimulus presentation elicits a large increase in the gamma synchronization of rhythmic neuronal activity in the input (granular) layers of V1, adaptation caused a pronounced increase in synchronization in the cortical output (supragranular) layers. The increase in gamma synchronization after adaptation was significantly correlated with an improvement in neuronal orientation discrimination performance only in the supragranular layers. Thus, synchronization between the spiking activity of individual neurons and their local population may enhance sensory coding to optimize network processing across laminar circuits.