A novel surface treatment for porous metallic implants that improves the rate of bony ongrowth.
A novel surface treatment for porous metallic implants that improves the rate of bony ongrowth.
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一种用于多孔金属植入物的新型表面处理方法，可提高骨生长速度。
DOI：
10.1002/jbm.a.31651
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
J. Schwartz
中科院分区：
文献类型：
--
作者：
F. Shannon;Jocelyn M. Cottrell;Xiang;Katherine N. Crowder;S. Doty;M. Avaltroni;R. Warren;T. Wright;J. Schwartz
快速植入物固定在从全关节置换术到创伤的一系列临床应用中可能是有益的。我们假设一种新型自组装单层膦酸盐分子（SAMP）共价键合到钛合金的氧化物表面将增强骨整合。珠状金属棒用三种涂层之一进行处理：SAMP、SAMP + RGD 肽或羟基磷灰石。将棒逆行插入 60 只兔子的两侧股骨远端。在第 2、4、8 和 16 周处死 15 只兔子。每次，每个涂层都有七个用于机械拉拔测试的样本和三个用于组织形态分析的样本。第四周时，与羟基磷灰石组相比，两个 SAMP 组的失效载荷均显着更高 (p < 0.01)。尽管单独使用 SAMP 的组在 16 周时仍然更强，但其他时间组之间没有发现显着差异。组织学显示所有三组周围都有丰富的新骨形成，但两个 SAMP 组的形成明显增强。通过这种新颖的治疗方法，无论是否使用 RGD，与羟基磷灰石相比，植入物的失效负荷在一半时间内翻倍。在早期种植体固定很重要的情况下，SAMP 治疗为骨科种植体的骨整合提供了一种简单且经济有效的增强方法。
Rapid implant fixation could prove beneficial in a host of clinical applications from total joint arthroplasty to trauma. We hypothesized that a novel self-assembled monolayer of phosphonate molecules (SAMP) covalently bonded to the oxide surface of titanium alloy would enhance bony integration. Beaded metallic rods were treated with one of three coatings: SAMP, SAMP + RGD peptide, or hydroxyapatite. Rods were inserted retrogradely into both distal femurs of 60 rabbits. Fifteen rabbits were sacrificed at 2, 4, 8, and 16 weeks. At each time, seven specimens for mechanical pull-out testing and three for histomorphometric analysis were available for each coating. At four weeks, both SAMP groups had significantly higher failure loads when compared to hydroxyapatite (p < 0.01). No significant differences were found among groups at other times, though the SAMP-alone group remained stronger at 16 weeks. Histology showed abundant new bone formation around all the three groups, though more enhanced formation was apparent in the two SAMP groups. With this novel treatment, with or without RGD, the failure load of implants doubled in half the time as compared with hydroxyapatite. Where early implant fixation is important, the SAMP treatment provides a simple, cost-effective enhancement to bony integration of orthopaedic implants.