Effect of environmental conditions on tear dynamics in soft contact lens wearers
Effect of environmental conditions on tear dynamics in soft contact lens wearers
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DOI：
10.1167/iovs.03-1185
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发表时间：
2004-08-01
影响因子：
4.4
通讯作者：
Kinoshita, S
中科院分区：
文献类型：
--
作者：
Maruyama, K;Yokoi, N;Kinoshita, S
目的。干眼症状通常与软性隐形眼镜（SCL）佩戴有关，并可能受到环境条件的影响。本研究旨在确定温度和湿度对SCL佩戴者泪膜的影响。所有11名入组受试者均为男性（平均年龄23.5±5.2 [SD]岁），均每日佩戴SCL。他们在不同的时段暴露在一个环境室内的四种不同条件下，空气温度（AT）和相对湿度（RH）分别为5度/10% （AT/RH）、15度/20%、25度/40%或35度/50%。采用两种不同类型的水凝胶SCL （SCL-a和SCL-b，含水量分别为72.0%和37.5%）。在视频半月板上通过测量有和没有SCL的撕裂半月板半径（TMR）来确定半月板撕裂体积。将隐形眼镜上的泪液干涉图案（TIPCL）分为5个等级（等级越高，膜越薄）。采用视频干涉仪记录有无scl的无创撕裂膜破裂时间（NIBUT）；同时对有无scl的眼干涩进行评分。在检查的环境条件下，没有或有SCL的TMR无显著差异，无论其类型如何。随着AT和RH的降低，TIPCL分级显著升高（CL-a: P = 0.042; CL-b: P = 0.002）， NIBUT显著降低（CL-a: P = 0.004; CL-b: P = 0.001），干燥评分显著升高（无SCL P = 0.023；有CL-a P = 0.009；有CL-b P = 0.003）。CL-a组的干燥评分高于CL-b组（15℃/20%时P = 0.011）。在相同的实验条件下，我们观察到在没有scl的情况下NIBUT没有显著变化。在scl存在的情况下，AT和RH对泪液体积明显没有影响。随着AT和RH的降低，SCL上的泪膜变薄，NIBUT变短，干燥度增加。当SCL的含水量较高时，眼睛干涩更明显。
PURPOSE. Dry eye symptoms are often associated with soft contact lens (SCL) wear and may be affected by environmental conditions. This study was conducted to determine the effects of temperature and humidity on the tear film in SCL wearers.METHODS. All 11 enrolled subjects were males (mean age, 23.5 +/- 5.2 [SD] years), and all wore SCL daily. They were exposed in different sessions to four different conditions in an environmental chamber with the air temperature (AT) and relative humidity (RH) set at 5degreesC/10% (AT/RH), 15degreesC/20%, 25degreesC/40%, or 35degreesC/50%. Two different types of hydrogel SCL (SCL-a and SCL-b; water content 72.0% and 37.5%, respectively) were used. The meniscus tear volume was determined on a video meniscometer by measuring the tear meniscus radius (TMR) with and without SCL. The tear interference patterns on the contact lens (TIPCL) were classified into five grades (the higher the grade, the thinner the film). Using a video interferometer, the non-invasive tear film breakup time (NIBUT) was recorded with and without SCLs; ocular dryness was also scored with and without SCLs.RESULTS. Under the environmental conditions examined, there were no significant differences in the TMR without or with SCL, regardless of their type. As AT and RH decreased, there was a significant increase in the TIPCL grade (CL-a: P = 0.042; CL-b: P = 0.002), a significant decrease in NIBUT (CL-a: P = 0.004; CL-b: P = 0.001), and a significant increase in the dryness score (without SCL P = 0.023; with CL-a P = 0.009; with CL-b P = 0.003). The dryness scores were higher with CL-a than CL-b (P = 0.011 at 15degreesC/20%). Under identical experimental conditions, we observed no significant change in NIBUT in the absence of an SCL.CONCLUSIONS. AT and RH apparently had no effect on the tear volume in the presence of SCLs. As AT and RH decreased, the tear film on the SCL became thinner, NIBUT became shorter, and dryness increased. Dryness was more pronounced in eyes with SCL of the higher water content.