Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research
Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research
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生物学黄金时代的药物化学：类固醇和肽研究的教训
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
R. Hirschmann
中科院分区：
文献类型：
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作者：
R. Hirschmann
生物学家和化学家之间的合作已经产生了对社会有巨大益处的药物。这种协同相互作用的动力结合了两种优势：化学的严谨性和生物学家从不同研究领域构建统一概念的能力。由此产生的对医学实践的贡献降低了发病率和死亡率，同时提高了生活质量。以罗宾逊、普雷洛格、伍德沃德和鲍林等化学家的工作为基础，药物化学家已经将合理的药物发现，特别是酶抑制剂的发现，推进到了二十年前难以想象的程度。药物化学对人类和动物健康的一些主要贡献直接源于结构和电子推理的创造性应用、仪器的进步以及生物学的巨大进步。然而，药物化学家才刚刚开始触及 20 世纪 50 年代“双螺旋革命”的影响所带来的机遇的表面。
Collaboration between biologists and chemists has generated medicines of enormous benefit to society. The dynamics of this synergistic interaction combines two strengths: the rigor of chemistry and the ability of biologists to construct unifying concepts from diverse fields of investigation. The resulting contributions to the practice of medicine have reduced morbidity and mortality while increasing the quality of life. Building on the work of chemists such as Robinson, Prelog, Woodward, and Pauling, medicinal chemists have advanced rational drug discovery, especially of enzyme inhibitors, to a degree unthinkable even twenty years ago. Some of the major contributions of medicinal chemistry to human and animal health stem directly from the creative application of structural and electronic reasoning, from advances in instrumentation, and from spectacular progress in biology. However, medicinal chemists have only begun to scratch the surface of the opportunities made possible by the impact of the “double-helix revolution” of the 1950s.