SYNTHESIS OF 1-O-ACYLGLYCEROL 2,3-CYCLIC PHOSPHATE - DETERMINATION OF THE ABSOLUTE STRUCTURE OF PHYLPA, A SPECIFIC INHIBITOR OF DNA-POLYMERASE ALPHA
SYNTHESIS OF 1-O-ACYLGLYCEROL 2,3-CYCLIC PHOSPHATE - DETERMINATION OF THE ABSOLUTE STRUCTURE OF PHYLPA, A SPECIFIC INHIBITOR OF DNA-POLYMERASE ALPHA
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DOI：
10.1016/s0040-4039(00)60612-3
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发表时间：
1993-06-18
影响因子：
1.8
通讯作者：
MURAKAMIMUROFUSHI, K
中科院分区：
文献类型：
--
作者：
KOBAYASHI, S;TOKUNOH, R;MURAKAMIMUROFUSHI, K
PHYLPA是一种DNA聚合酶α的特异性抑制剂，以对映选择性方式合成了四种可能的立体异构体。检测了这些异构体对DNA聚合酶α的抑制活性，并确定PHYLPA的结构为1-O-[（9 ′ S，10 ′ R）-9 ′，10 ′-甲酰基十六烷酰基]-sn-甘油2，3-环磷酸钠。
Four possible stereoisomers of PHYLPA, a specific inhibitor of DNA polymerase alpha, were synthesized in enantioselective manners. These isomers were examined for inhibition activity for DNA polymerase alpha, and the structure of PHYLPA was established as sodium 1-O-[(9'S, 10'R)-9',10'-methanohexadecanoyl]-sn-glycerol 2,3-cyclic phosphate.