A Swedish national twin study of lifetime major depression
A Swedish national twin study of lifetime major depression
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DOI：
10.1176/appi.ajp.163.1.109
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发表时间：
2006-01-01
影响因子：
17.7
通讯作者：
Pedersen, NL
中科院分区：
文献类型：
--
作者：
Kendler, KS;Gatz, M;Pedersen, NL
目的：大量证据支持终生重度抑郁症的遗传性。不太清楚的是，严重抑郁症的遗传影响是否对女性比男性更重要，以及遗传风险因素在两性中是否相同。目前尚不清楚遗传对抑郁症的影响是否在历史队列中是恒定的。方法：在瑞典国家双胞胎登记处的42,161对双胞胎中，包括15,493对完整的双胞胎，在个人访谈中根据修改的DSM-IV标准评估终生抑郁症。结果：模型拟合结果表明，女性患重度抑郁症的遗传率(42%)显著高于男性(29%)，男性和女性患重度抑郁症的遗传危险因素呈中度相关。在1900-1958年出生的三个队列中，遗传和环境因素在重度抑郁症的病因中的作用没有显著差异。结论：在迄今为止最大的样本中，终生重度抑郁症是适度可遗传的，其估计与以前的研究相似。这项研究与之前的一些研究一致，但不是其他研究，这项研究表明，女性患重度抑郁症的遗传率高于男性，而且一些导致重度抑郁症的遗传风险因素的影响具有性别特异性。没有证据表明，在近60年的出生队列中，遗传和环境风险因素在严重抑郁症中所起的作用存在差异。
Objective: Substantial evidence supports the heritability of lifetime major depression. Less clear is whether genetic influences in major depression are more important in women than in men and whether genetic risk factors are the same in the two sexes. It is not known whether genetic effects on major depression are constant across historical cohorts.Method: Lifetime major depression was assessed at personal interview by modified DSM-IV criteria in 42,161 twins, including 15,493 complete pairs, from the national Swedish Twin Registry. Twin models were evaluated by using the program Mx.Results: Model fitting indicated that the heritability of liability to major depression was significantly higher in women (42%) than men (29%) and the genetic risk factors for major depression were moderately correlated in men and women. No significant differences were seen in the etiologic roles of genetic and environmental factors in major depression in three cohorts spanning birth years 1900-1958.Conclusions: In the largest sample to date, lifetime major depression was moderately heritable, with estimates similar to those in prior studies. In accord with some but not other previous investigations, this study suggests both that the heritability of major depression is higher in women than in men and that some genetic risk factors for major depression are sex-specific in their effect. No evidence was found for differences in the roles of genetic and environmental risk factors in major depression in birth cohorts spanning nearly six decades.