In vitro evaluation of alginate beads of a diclofenac salt
In vitro evaluation of alginate beads of a diclofenac salt
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DOI：
10.1016/s0378-5173(97)00333-5
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发表时间：
1998-03-18
影响因子：
5.8
通讯作者：
Fell, JT
中科院分区：
文献类型：
--
作者：
Fernandez-Hervas, MJ;Holgado, MA;Fell, JT
将含有双氯芬酸羟乙基吡咯烷的海藻酸盐珠与乌达木或壳聚糖配制成肠溶制剂。在所有情况下，捕获效率都很高。对断裂珠的检查显示在藻酸珠中有一个内部空隙。相比之下，壳聚糖-海藻酸酯微球由于聚合物间络合物的存在而具有致密均匀的内部结构。还观察了壳聚糖与药物的相互作用。在模拟胃的条件下，少量的药物被释放出来。海藻酸盐-壳聚糖微球的释放行为取决于pH值和海藻酸盐-壳聚糖的比例。(C) 1998 Elsevier Science B.V.版权所有
Alginate beads containing diclofenac hydroxyethylpyrrolidine were formulated with either Eudragit or chitosan in order to achieve an enteric formulation. In all cases, high entrapment efficiencies were obtained. The examination of fractured beads revealed an internal void in the Eudragit-alginate beads. In contrast, a dense homogeneous internal structure was observed in the chitosan-alginate beads due to interpolymeric complex. An interaction between chitosan and drug was also observed. Under conditions mimicking those in the stomach, a small amount of drug was released. The alginate-chitosan beads showed a release behaviour dependent on pH value and alginate-chitosan ratio. (C) 1998 Elsevier Science B.V. All rights reserved.