Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway.
Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway.
复制标题
Shizukaol D 是一种从金粟兰 (Chloranthus serratus) 中分离出来的二聚倍半萜，通过调节 Wnt 信号通路抑制人肝癌细胞的生长。
DOI：
10.1371/journal.pone.0152012
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Yu L
中科院分区：
文献类型：
--
作者：
Tang L;Zhu H;Yang X;Xie F;Peng J;Jiang D;Xie J;Qi M;Yu L
天然产物已成为开发用于治疗癌症的新药的来源。为了寻找抑制肝癌生长的候选化合物，测试了金粟兰的成分。在这里，我们报告，shizukaol D，二聚体倍半萜从金粟兰，肝癌细胞的生长抑制作用，在剂量和时间依赖性的方式。我们证明，shizukaol D诱导细胞进行凋亡。更重要的是，shizukaol D减弱Wnt信号传导并降低内源性Wnt靶基因的表达，这导致β-连环蛋白的表达降低。总之，本研究表明，shizukaol D通过调节Wnt通路抑制肝癌细胞的生长。
Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner. We demonstrated that shizukaol D induced cells to undergo apoptosis. More importantly, shizukaol D attenuated Wnt signalling and reduced the expression of endogenous Wnt target genes, which resulted in decreased expression of β-catenin. Collectively, this study demonstrated that shizukaol D inhibited the growth of liver cancer cells by modulating Wnt pathway.