Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012.
Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012.
复制标题
DOI：
10.1186/s12879-015-1126-2
复制
发表时间：
2015-10-01
影响因子：
3.7
通讯作者：
Shen K
中科院分区：
文献类型：
--
作者：
Liu C;Xiao Y;Zhang J;Ren L;Li J;Xie Z;Xu B;Yang Y;Qian S;Wang J;Shen K
人腺病毒(HAdV)在儿童呼吸道感染中起重要作用。到目前为止，已发现60多种HAdV。本文介绍了北京地区急性下呼吸道感染(ALRTI)患儿的HAdV型别特征及住院HAdV感染病例的临床特征和实验室检查结果。呼吸道标本收集自2007年3月至2012年12月在急诊科就诊的儿科ALRTI患者或北京儿童医院收治的患者。用聚合酶链式反应或逆转录-聚合酶链式反应检测常见呼吸道病毒感染情况。HAdV阳性标本进一步用聚合酶链式反应和测序进行分型。在3356例ALRTI患者中，194例(5.8%)检出HAdV感染。HAdV感染主要集中在5岁以下儿童(88.35%)。研究期间共检出11种不同类型的HAdV，其中HAdV-B7(49.0%)和HAdV-B3(26.3%)是最常见的HAdV，其次是HAdV-C2(7.7%)和HAdVC1型(4.6%)。新出现和再次出现的病毒类型或变异株分别为HAdV-B55(n = 5)、HAdV-C57(n = 3)和HAdV-B14p1(n = 1)。结果还包括报告的首例HAdV-C2和HAdV-C57混合感染病例。单纯甲型肝炎病毒感染者(n = 49例)与甲型肝炎病毒/呼吸道合胞病毒混合感染者(n = 41例)临床特征相似。HAdV-B7感染患者的发热持续时间和血清肌酶水平高于HAdV-B3感染患者。在研究期间，HAdV-B7和HAdV-B3是在儿童ALRTIs中鉴定的主要类型。HAdV-B7感染往往具有更严重的临床后果。新出现的类型或变种以及与不同类型的HAdV混合感染的存在突显了对HAdV感染进行持续和密切监测的必要性。
Human adenoviruses (HAdV) play a significant role in pediatric respiratory tract infections. To date, over 60 types of HAdV have been identified. Here, HAdV types are characterized in children in the Beijing area with acute lower respiratory tract infections (ALRTIs) and the clinical features and laboratory findings of hospitalized HAdV-infected cases are described. Respiratory specimens were collected from pediatric patients with ALRTIs in the emergency department or from those admitted to Beijing Children’s Hospital between March 2007 and December 2012. Infections with common respiratory viruses were determined by PCR or RT-PCR. HAdV positive samples were further typed by PCR and sequencing. Among 3356 patients with ALRTIs, 194 (5.8 %) were found to have HAdV infection. HAdV infection was primarily confined to children (88.35 %) less than 5 years of age. A total of 11 different types of HAdV were detected throughout the study period, with HAdV-B7 (49.0 %) and HAdV-B3 (26.3 %) as the most prevalent types, followed by HAdV-C2 (7.7 %) and HAdVC1 (4.6 %). Newly emerging and re-emergent types or variants, HAdV-B55 (n = 5), HAdV-C57 (n = 3), and HAdV-B14p1 (n = 1), were identified. Results also included the reported first case of co-infection with HAdV-C2 and HAdV-C57. Clinical entities of patients with single HAdV infection (n = 49) were similar to those with mixed HAdV/respiratory syncytial virus (RSV) infections (n = 41). Patients with HAdV-B7 infection had longer duration of fever and higher serum levels of muscle enzymes than HAdV-B3-infected patients. During the study period, HAdV-B7 and HAdV-B3 were the predominant types identified in pediatric ALRTIs. HAdV-B7 infection tends to have more severe clinical consequences. The presence of newly emerging types or variants and co-infection with different types of HAdV highlights the need for constant and close surveillance of HAdV infection.