The bone mineral density in childhood study: Bone mineral content and density according to age, sex, and race
The bone mineral density in childhood study: Bone mineral content and density according to age, sex, and race
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DOI：
10.1210/jc.2006-2553
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发表时间：
2007-06-01
影响因子：
5.8
通讯作者：
Shepherd, John A.
中科院分区：
文献类型：
--
作者：
Kalkwarf, Heidi J.;Zemel, Babette S.;Shepherd, John A.
背景：低骨量可能会增加骨折的风险。一些慢性疾病，药物和生活方式因素影响骨矿物质积累。目的：建立儿童骨矿物质含量（BMC）和骨密度（BMD）的参考曲线。设计和设置：儿童骨矿物质密度研究是一项正在进行的纵向研究，每年在美国的五个临床中心进行测量。参与者：参与者包括1554名健康儿童（761名男性，793名女性），年龄6-16岁，所有ethnicity.Main结果措施：扫描的全身，腰椎，髋关节，前臂获得使用双能X射线吸收法。百分位数曲线的基础上，每年三次测量产生的LMS statistical procedure.Results：BMC的全身和腰椎和全身，腰椎，全髋关节，股骨颈，前臂的BMD是由特定的females的性别，年龄和种族（黑人与非黑人）。在所有骨骼部位，黑人的BMC和BMD均高于黑人（P < 0.0001）。BMC和BMD随年龄增长而增加，16岁（女孩）或17岁（男孩）的平台期不明显。BMC和BMD的变化也随着年龄的增长而增加。结论：年龄，种族和性别特异性的参考曲线可以用来帮助识别儿童骨缺损和监测骨的变化，在应对慢性疾病或治疗。
Context: Low bone mass may increase risk of fracture. Several chronic medical conditions, medications, and lifestyle factors affect bone mineral accrual. Appropriate reference values are essential for identification of children with bone deficits.Objective: Our objective was to establish reference curves for bone mineral content (BMC) and density (BMD) in children.Design and Setting: The Bone Mineral Density in Childhood Study is an ongoing longitudinal study in which measurements are obtained annually at five clinical centers in the United States.Participants: Participants included 1554 healthy children (761 male, 793 female), ages 6-16 yr, of all ethnicities.Main Outcome Measures: Scans of the whole body, lumbar spine, hip, and forearm were obtained using dual-energy x-ray absorptiometry. Percentile curves based on three annual measurements were generated using the LMS statistical procedure.Results: BMC of the whole body and lumbar spine and BMD of the whole body, lumbar spine, total hip, femoral neck, and forearm are given for specific percentiles by sex, age, and race (Black vs. non-Black). BMC and BMD were higher for Blacks at all skeletal sites (P < 0.0001). BMC and BMD increased with age, and a plateau was not evident by age 16 (girls) or age 17 (boys). The variation in BMC and BMD also increased with age.Conclusions: Age-, race-, and sex-specific reference curves can be used to help identify children with bone deficits and for monitoring changes in bone in response to chronic diseases or therapies.