Straightforward and highly efficient catalyst-free one-pot synthesis of dithiocarbamates under solvent-free conditions
Straightforward and highly efficient catalyst-free one-pot synthesis of dithiocarbamates under solvent-free conditions
复制标题
DOI：
10.1021/ol0620141
复制
发表时间：
2006-11-09
期刊：
影响因子：
5.2
通讯作者：
Saidi, Mohammad R.
中科院分区：
文献类型：
--
作者：
Azizi, Najmedin;Aryanasab, Fezzeh;Saidi, Mohammad R.
基于胺、CS2和卤代烷在无溶剂条件下不使用催化剂的一锅反应，可以高效且简单地合成二硫代氨基甲酸酯。该方法反应条件温和，产率高，反应范围广，具有良好的合成实用性。该反应是制备S-烷基硫代氨基甲酸酯的高度原子经济的方法，并且可以成功地大量用于制药或农业化学工业。
A highly efficient and simple synthesis of dithiocarbamates is possible based on the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochemical industries.