Imprecision of Creatinine-Based GFR Estimates in Uninephric Kidney Donors
Imprecision of Creatinine-Based GFR Estimates in Uninephric Kidney Donors
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DOI：
10.2215/cjn.05280709
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发表时间：
2010-03-01
影响因子：
9.8
通讯作者：
Myers, Bryan D.
中科院分区：
文献类型：
--
作者：
Tan, Jane C.;Ho, Bing;Myers, Bryan D.
背景和目标：为了确保活体肾脏捐赠者的长期安全，现在建议在捐赠后对其进行至少2年的随访，并监测血清肌酐水平。此类水平通常由临床实验室进行估计方程计算，并报告为估计 GFR (eGFR)。这些方程在非肾脏活体捐赠者中的准确性尚未得到验证。这对于老年活体捐献者尤其重要，他们经常患有与衰老相关的 GFR 抑郁症。设计、环境、参与者和测量：我们比较了尿肌酐清除率、肾脏疾病估计方程 (eGFR) 中四变量饮食调整以及最近报道的 CKD-EPI GFR 估计方程与 64 名肾脏捐赠后受试者的尿碘酞酸盐清除率 (iGFR) 测量的真实 GFR。结果：肌酐清除率高估iGFR。两个基于肌酐的估计方程与 iGFR 相关性较差，并且低估了 iGFR。超过一半的肾脏捐赠者有 eGFR
Background and objectives: To ensure long-term safety of living kidney donors, it is now recommended that they be followed for at least 2 years after donation and that serum creatinine levels be monitored. Such levels are often subjected by clinical laboratories to estimating equations and are reported as estimated GFR (eGFR). The accuracy of such equations in uninephric living donors has yet to be validated. This is especially important in older living donors, who often have senescence-related depression of GFR.Design, setting, participants, & measurements: We compared urinary creatinine clearance, four-variable Modification of Diet in Renal Disease estimating equation (eGFR), and the recently reported CKD-EPI GFR estimating equation with true GFR measured by the urinary iothalamate clearance (iGFR) in 64 subjects after kidney donation.Results: Creatinine clearance overestimated iGFR. Both creatinine-based estimating equations were poorly correlated with and underestimated iGFR. More than half of kidney donors had eGFR