Smoking and panic attacks -: An epidemiologic investigation
Smoking and panic attacks -: An epidemiologic investigation
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DOI：
10.1001/archpsyc.56.12.1141
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发表时间：
1999-12-01
影响因子：
--
通讯作者：
Klein, DF
中科院分区：
文献类型：
--
作者：
Breslau, N;Klein, DF
背景：流行病学研究已经报道了吸烟和惊恐障碍之间的终生联系。在这项研究中，我们探讨潜在的解释，这种association.Methods：分析数据进行了流行病学研究，在密歇根州东南部的年轻人的流行病学研究（N = 1007）和全国科摩罗调查烟草补充（N = 4411）。考克斯：使用具有时间依赖性协变量的比例风险模型来估计与先前吸烟相关的惊恐发作的风险，反之亦然，控制重性抑郁症的病史。肺部疾病在吸烟恐慌发作associations.Results的作用：每日吸烟的信号增加的风险首次发生恐慌发作和障碍，风险高于活跃比过去的吸烟者。在先前有惊恐发作或惊恐障碍的人中，没有发现每日吸烟的显著风险。探索性分析表明，肺部疾病可能是一个机制，吸烟与恐慌attacks.Conclusions：证据表明，吸烟和恐慌症之间的关联可能主要是从一个方向的影响（即，从以前的吸烟到第一次恐慌发作）和可能性更高的风险比过去的吸烟者主动吸烟的因果关系的假设。
Background: Epidemiologic studies have reported a lifetime association between smoking and panic disorder. In this study, we examine potential explanations for this association.Methods: Analysis was conducted on data from 2 epidemiologic studies, the Epidemiologic Study of Young Adults in southeast Michigan (N = 1007) and the National Comorbidity Survey Tobacco Supplement (n = 4411). Cox: proportional hazards models with time-dependent covariates were used to estimate the risk for onset of panic attacks associated with prior smoking and vice versa, controlling for history of major depression. The role of lung disease in the smoking-panic attacks association was explored.Results: Daily smoking signaled an increased risk for first occurrence of panic attack and disorder; the risk was higher in active than past smokers. No significant risk was detected for onset of daily smoking in persons with prior panic attacks or disorder. Exploratory analyses suggest that lung disease might be one of the mechanisms linking smoking to panic attacks.Conclusions: The evidence that the association between smoking and panic disorder might result primarily from an influence in one direction (ie, from prior smoking to first panic attack) and the possibility of a higher risk in active than past smokers suggest a causal hypothesis for the smoking-panic attacks relationship.