Transcriptional Regulation of Type I Receptor Tyrosine Kinases in the Mammary Gland
Transcriptional Regulation of Type I Receptor Tyrosine Kinases in the Mammary Gland
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DOI：
10.1023/a:1026303814855
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发表时间：
1997-04-01
影响因子：
2.5
通讯作者：
Hurst, Helen C.
中科院分区：
文献类型：
--
作者：
Bates, Nicholas P.;Hurst, Helen C.
人类 EGFR(3) 和 ERBB2 基因的转录调控已得到广泛研究，特别是在乳腺癌中过度表达的情况下。在这里，我们总结了已发表的工作，详细介绍了与这些基因和大鼠 ERBB2 同源基因 neu 基因的启动子相互作用的转录因子，并讨论了它们与癌症中基因激活的可能相关性。此外，我们回顾了调节这些基因表达的具有生物学意义的分子，并讨论了参与介导这些反应的核因子。我们还描述了这些研究可能产生的新疗法，并强调了控制正常乳腺和乳腺癌中 EGFR 和 ERBB2 基因表达的未来研究方向。
The transcriptional regulation of the human EGFR(3) and ERBB2 genes has been extensively studied, particularly in the context of their overexpression in breast cancer. Here we summarize published work detailing the transcription factors which interact with the promoters of these and the rat ERBB2 homologue, neu, genes and discuss their possible relevance to gene activation in cancer. In addition we review the biologically significant molecules which modulate expression of these genes and discuss the nuclear factors involved in mediating these responses. We also describe novel therapies which may result from these studies and highlight directions for future research into the control of expression of the EGFR and ERBB2 genes in the normal mammary gland and in breast cancer.