Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.
Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.
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相位幅度耦合的时机对于青少年视听整合的神经元和功能成熟至关重要。
DOI：
10.1002/brb3.1635
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hiraki K
中科院分区：
文献类型：
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作者：
Ohki T;Matsuda T;Gunji A;Takei Y;Sakuma R;Kaneko Y;Inagaki M;Hanakawa T;Ueda K;Fukuda M;Hiraki K
目的青少年的视听信息整合能力发育较晚，但其神经元机制尚不清楚。最近的研究表明，神经元振荡的相位-振幅耦合（PAC），即低频相位对高频振幅的调制，与成人的视听整合有关。因此，我们研究了PAC在青少年中是如何发展的，以及它是否与视听整合功能成熟有关。我们特别关注PAC（或耦合相位）的时序，其定义为具有最大高频幅值的低频相位。方法对15名成人和14名青少年进行视听语音整合任务时使用脑磁图（MEG），通过逐个试验的分析，研究了关联皮层中的PAC。结果：虽然δ - β偶联在成人和青少年中都被一致观察到，但我们发现与成人相比，青少年δ - β PAC的时间延迟了20-40毫秒。此外，逻辑回归分析显示，当右颞极（TP） delta - beta PAC的时间越接近波谷位置（180度）时，任务表现越好。结论在青少年的发展过程中，PAC的时间对音像信息的结合至关重要。
ObjectiveThe ability to integrate audiovisual information matures late in adolescents, but its neuronal mechanism is still unknown. Recent studies showed that phase‐amplitude coupling (PAC) of neuronal oscillations, which is defined as the modulation of high‐frequency amplitude by low‐frequency phase, is associated with audiovisual integration in adults. Thus, we investigated how PAC develops in adolescents and whether it is related to the functional maturation of audiovisual integration. In particular, we focused on the timing of PAC (or the coupling phase), which is defined as the low‐frequency phase with maximum high‐frequency amplitude.MethodsUsing magnetoencephalography (MEG) on 15 adults and 14 adolescents while they performed an audiovisual speech integration task, we examined PAC in association cortexes with a trial‐by‐trial analysis.ResultsWhereas delta‐beta coupling was consistently observed in both adults and adolescents, we found that the timing of delta‐beta PAC was delayed by 20–40 milliseconds in adolescents compared with adults. In addition, a logistic regression analysis revealed that the task performance improves as the timing of delta‐beta PAC in the right temporal pole (TP) got closer to the trough position (180 degrees).ConclusionThese results suggest that the timing of PAC is essential for binding audiovisual information and underlies the developmental process in adolescents.