Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis
Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis
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DOI：
10.3748/wjg.v20.i28.9458
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发表时间：
2014-07-28
影响因子：
4.3
通讯作者：
Santana, Genoile Oliveira
中科院分区：
文献类型：
--
作者：
da Silva, Bruno Cesar;Lyra, Andre Castro;Santana, Genoile Oliveira
溃疡性结肠炎（UC）是一种以结肠和直肠粘膜弥漫性炎症为特征的慢性疾病。UC的标志性临床症状是带血腹泻。临床过程的特点是恶化和缓解，这可能是自发发生的，也可能是对治疗变化或并发疾病的反应。UC最常见于青春期晚期或成年早期，但它可以发生在任何年龄。近几十年来，UC的发病率在世界范围内有所增加，特别是在发展中国家。相反，在此期间，治疗方法的进步提高了病人的预期寿命，死亡率也随着时间的推移而下降。重要的是要强调，UC的表型表现有相当大的可变性。在这种情况下，某些临床和人口学特征对确定倾向于疾病发展更严重和预后差的患者是有用的。在这组患者中，更好的临床监测和更强化的治疗可能会改变疾病的自然进程。本文的目的是回顾UC的流行病学和人口学特征以及可能与其临床预后相关的因素。（三）2014年百世登出版集团股份有限公司版权所有。
Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and rectum. The hallmark clinical symptom of UC is bloody diarrhea. The clinical course is marked by exacerbations and remissions, which may occur spontaneously or in response to treatment changes or intercurrent illnesses. UC is most commonly diagnosed in late adolescence or early adulthood, but it can occur at any age. The incidence of UC has increased worldwide over recent decades, especially in developing nations. In contrast, during this period, therapeutic advances have improved the life expectancy of patients, and there has been a decrease in the mortality rate over time. It is important to emphasize that there is considerable variability in the phenotypic presentation of UC. Within this context, certain clinical and demographic characteristics are useful in identifying patients who tend to have more severe evolution of the disease and a poor prognosis. In this group of patients, better clinical surveillance and more intensive therapy may change the natural course of the disease. The aim of this article was to review the epidemiology and demographic characteristics of UC and the factors that may be associated with its clinical prognosis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.