PROGNOSIS OF THE ADENOCARCINOMA OF THE CERVIX UTERI - A COMPARATIVE-STUDY
PROGNOSIS OF THE ADENOCARCINOMA OF THE CERVIX UTERI - A COMPARATIVE-STUDY
复制标题
DOI：
10.1016/0090-8258(89)90032-2
复制
发表时间：
1989-11-01
影响因子：
4.7
通讯作者：
PFLEIDERER, A
中科院分区：
文献类型：
--
作者：
KLEINE, W;RAU, K;PFLEIDERER, A
通过配对分析证明了宫颈腺癌和鳞状细胞癌患者的不同预后。以1:2的比例对1964年至1985年间接受治疗的144名腺癌患者与268名在年龄、分期和治疗方式上具有可比性的鳞状细胞癌患者进行了比较。两组患者中，45% 的患者处于 I 期，38% 处于 II 期，15% 处于 III 期，2% 处于 IV 期。腺癌患者的五年和十年生存率显着低于鳞状细胞癌患者（分别为 53% 和 42% vs 68% vs 58%，P = 0.006）。根据临床分期对患者预后进行分析，仅接受放射治疗的 III 期和 IV 期患者的两组之间没有显着差异。接受根治性手术治疗的 I 期和 II 期患者没有发现显着差异。然而，预后最显着的差异出现在接受放射治疗的 I 期和 II 期患者中。 I 期腺癌的五年生存率为 58.6%，而鳞状细胞癌的五年生存率为 85.0%。从这些结果可以得出结论，讨论FIGO分期问题比讨论这两种组织学类型的不同放射敏感性更有必要。手术治疗必须与根治性手术或分期剖腹手术具有相同的优先级，以对子宫颈腺癌进行准确的组织学分期。
The different prognoses for patients with adenocarcinomas and squamous cell carcinomas of the cervix uteri were proved by matched-pair analysis. One hundred forty-four patients with adencarcinoma treated in 1964-1985 were compared in a ratio of 1:2 with 268 patients with squamous cell carcinoma comparable in age, stage, and treatment modality. In both groups 45% of patients were in stage I, 38% in stage II, 15% in stage III, and 2% in stage IV. Five- and 10-year survivals of patients with adenocarcinoma were significantly lower than for those with squamous cell carcinoma (53% resp. 42% vs 68% vs 58%, P = 0.006). In an analyses of patients'' prognosis according to clinical stage there was no significant difference between both groups in stages III and IV treated exclusively by radiotherapy. No significant differences were found in stage I and II patients treated by radical surgery. However, the most significant difference in prognosis was seen in stage I and II patients treated by radiotherapy. Five-year survival was 58.6% in stage I adenocarcinomas compared with 85.0% in squamous cell carcinomas. It can be concluded from these results that a discussion of the problem of FIGO staging is more necessary than a discussion of the different radiosensitivities of these two histological types. Surgical treatment must have the same priority as radical surgery or staging laparotomy for exact histologic staging in adenocarcinomas of the cervix uteri.