Immune modulation: the genetic approach
Immune modulation: the genetic approach
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DOI：
10.1016/s0165-2427(02)00075-2
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发表时间：
2002-09-10
影响因子：
1.8
通讯作者：
der Laan, MHP
中科院分区：
文献类型：
--
作者：
der Laan, MHP
作为抗击疾病的综合战略的一部分，提高动物对疾病的遗传抵抗力，从而提高动物的免疫能力是越来越可取的，然而，仍然需要研究开发可能被使用的遗传工具。在这个搜索中，为各种免疫反应选择的线被用来研究相关的免疫标记物。经过六个世代的选择，鸡的体内免疫反应有三种不同：高抗体应答、高细胞免疫应答和高吞噬活性。选择一个性状的每个品系，对该性状的免疫能力都有显著提高。此外，结果表明，所分析的三种免疫反应之间明显独立，这意味着需要一种全局方法来提高免疫能力。选定的品系允许跟随与免疫反应基因相关联的遗传标记。在不同的品系中，观察到不同的MHC基因频率模式，MHC等位基因的作用因免疫性状而异。免疫反应与生产性状之间存在一定的相关性。这些被选中的品系将被用来寻找其他“已知”的免疫反应基因或“匿名”的遗传标记，这可能成为未来调节动物免疫反应的工具。(C)2002 Elsevier Science B.V.保留所有权利。
As part of a comprehensive strategy to combat diseases, improving genetically resistance to diseases and therefore immune capacities of animals is more and more desirable, However, research is still needed to develop genetic tools, that may be used. In this search, lines selected for various immune responses are used to study relevant immune markers. Chickens have been selected for six generations for three different in vivo immune responses: high antibody response, high cell-mediated immune response and high phagocytic activity. Each line, selected for one trait, showed significant increase in immune capacity for this trait. In addition, results showed clearly independence between the three immune responses analyzed, meaning that a global approach is needed to improve immune capacity. Selected lines allow to follow genetic markers linked to immune response genes. In the different lines, different patterns in MHC gene frequency were observed and MHC alleles differed in their effects according to the immune trait. Some correlations were found between immune responses and production traits. The selected lines will be used to find other "known" immune response genes or "anonymous" genetic markers, which may become the future tools to modulate immune responsiveness of animals. (C) 2002 Elsevier Science B.V. All rights reserved.