The clinical significance of papillitis of the major duodenal papilla
The clinical significance of papillitis of the major duodenal papilla
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DOI：
10.1067/mge.2002.124559
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发表时间：
2002-06-01
影响因子：
7.7
通讯作者：
Min, YI
中科院分区：
文献类型：
--
作者：
Park, JS;Kim, MH;Min, YI
背景本研究探讨十二指肠乳头炎的临床意义，并分析胆胰疾病患者内镜下乳头炎与组织学乳头炎的相关性。方法：87例患者和12例健康对照者入选。乳头炎的内镜表现由两名盲法内镜医师进行分类，并从乳头取活检标本。各种因素进行了前瞻性分析，以确定任何关系与内镜严重程度的乳头literation.Results：通过单因素分析，临床急性炎症状态和血清转氨酶水平升高与中度和重度内镜乳头炎（p < 0.05）。然而，通过多变量分析，只有临床急性炎症状态与中度和重度内镜乳头炎显著相关（p < 0.001）。内镜下乳头炎的严重程度与单核细胞浸润相关性较差，但与中性粒细胞浸润相关性良好。中度和严重的乳头炎，没有观察到在健康volunteers.Conclusions：中度和重度内镜乳头炎是显着更常见的胆道或胰腺疾病加上临床急性炎症条件的患者，而中度和重度乳头炎没有观察到在健康志愿者。中度和重度内镜乳头炎是胆道或胰腺疾病的特征。
Background. This study investigated the clinical significance of papillitis of the major duodenal papilla and analyzed the correlation between endoscopic and histologic papillitis in patients with biliary or pancreatic disorders. Methods: Eighty-seven patients and 12 healthy control subjects were enrolled. The endoscopic appearance of papillitis was classified by two blinded endoscopists, and biopsy specimens were taken of the papilla. Various factors were prospectively analyzed to identify any relationship with the endoscopic severity of the papillitis.Results: By univariate analysis, a clinically acute inflammatory condition and elevation of serum transaminase levels were significantly associated with moderate and severe endoscopic papillitis (p < 0.05). However, by multivariate analysis, only a clinically acute inflammatory condition was significantly associated with moderate and severe endoscopic papillitis (p < 0.001). The endoscopic severity of papillitis was poorly correlated with monocyte infiltration, but there was a good correlation with neutrophil infiltration. Moderate and severe papillitis were not observed in healthy volunteers.Conclusions: Moderate and severe endoscopic papillitis were significantly more common in patients with biliary or pancreatic disorders plus a clinically acute inflammatory condition, whereas moderate and severe papillitis were not observed in healthy volunteers. Moderate and severe endoscopic papillitis are characteristic of biliary or pancreatic disorders.