Development - Parthenogenetic stem cells in nonhuman primates
Development - Parthenogenetic stem cells in nonhuman primates
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DOI：
10.1126/science.1065637
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发表时间：
2002-02-01
期刊：
影响因子：
56.9
通讯作者：
West, MD
中科院分区：
文献类型：
--
作者：
Cibelli, JB;Grant, KA;West, MD
单性生殖是一个卵子在没有精子的情况下发育成胚胎的过程。这一过程在一定程度上已在非人灵长类动物中得到了表征（1，2）;然而，迄今为止，尚未衍生出灵长类动物孤雌生殖胚胎干（ES）细胞系。虽然获得足月小鼠和牛孤雌生殖个体的尝试失败了（3-5），但孤雌生殖细胞与双亲来源的胚胎组织的嵌合体产生了明显正常的后代
Parthenogenesis is the process by which an egg can develop into an embryo in the absence of sperm. This process has been characterized to some extent in nonhuman primates (1, 2); however, to date, no primate parthenogenetic embryonic stem (ES) cell lines have been derived. Although attempts to obtain full-term mouse and bovine parthenogenetic individuals have failed (3–5), chimeras of parthenogenetic cells with biparentally derived embryonic tissues have generated apparently normal offspring