The winner and loser effect, serotonin transporter genotype, and the display of offensive aggression
The winner and loser effect, serotonin transporter genotype, and the display of offensive aggression
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DOI：
10.1016/j.physbeh.2011.04.021
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发表时间：
2011-07-06
影响因子：
2.9
通讯作者：
Sachser, Norbert
中科院分区：
文献类型：
--
作者：
Kloke, Vanessa;Jansen, Friederike;Sachser, Norbert
攻击性行为是遗传和环境因素复杂相互作用的结果。攻击的主要调节因子包括分子水平上的血清素能系统和作为环境因素的先前攻击竞赛的经验。本研究旨在阐明不同5-羟色胺转运体（5-HTT）基因型的成年雄性小鼠，战斗经历对其攻击性行为表现的影响。5-HTT +/+、5-HTT +/-和5-HTT -/-小鼠连续三天分别给予输赢体验，随后观察它们作为居民对来自C3H菌株的温顺入侵者的攻击性行为。研究的主要发现是：基因型在攻击性行为的数量上没有显著差异。胜利者对入侵者表现出更多的投入，攻击他的速度更快，总体上表现出比失败者更高的攻击性得分。没有显著的x基因型社会经验相互作用：在所有3种5-HTT基因型中，输赢对攻击性攻击行为有相似的影响。我们得出的结论是，社会经验是赢家还是输家，而不是5-HTT基因型决定了对温顺入侵者的行为。(C) 2011爱思唯尔公司版权所有。
Aggressive behaviour results from a complex interplay between genetic and environmental factors. Key modulators of aggression include the serotonergic system on the molecular level and experience in prior aggressive contests as an environmental factor. The aim of this study was to elucidate the effects of fighting experience on the display of offensive aggressive behaviour in adult male mice varying in serotonin transporter (5-HTT) genotype. 5-HTT +/+, 5-HTT +/- and 5-HTT -/- mice were given either a winning or a losing experience on each of three consecutive days and were subsequently observed for their offensive aggressive behaviour as residents against a docile intruder from the C3H strain in a resident-intruder paradigm. The main findings were: There was no significant difference between the amount of offensive aggressive behaviour displayed by the genotypes. Winners showed more engagement with the intruder, attacked him faster and exhibited overall higher aggression scores than losers. There was no significant genotype x social experience interaction: winning and losing had a similar effect on offensive aggressive behaviour in all three 5-HTT genotypes. We conclude that social experience in terms of having been a winner or having been a loser rather than the 5-HTT genotype determines the behaviour towards a docile intruder. (C) 2011 Elsevier Inc. All rights reserved.