Extended amygdala, conditioned withdrawal and memory consolidation
Extended amygdala, conditioned withdrawal and memory consolidation
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DOI：
10.1016/j.pnpbp.2021.110435
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发表时间：
2021-09-20
影响因子：
5.6
通讯作者：
Leri, Francesco
中科院分区：
文献类型：
--
作者：
Baidoo, Nana;Leri, Francesco
阿片类戒断可以通过经典条件反射与环境线索相关联。暴露于这些线索可以促使戒断受试者进入条件性戒断状态，并且有迹象表明，条件性戒断可以部分通过促进记忆的储存来延续成瘾循环。这篇综述讨论了支持这一假设的证据，即条件性戒断通过激活涉及扩展杏仁核的神经回路来促进记忆巩固。具体来说，中央杏仁核，终纹床核，和核壳功能相互作用，在撤退，介导的条件反应的表达，并涉及记忆巩固。从这个角度来看，延伸的杏仁核可能是一个神经通路，通过它，在条件性戒断状态下进行的药物寻求行为更有可能成为习惯性和持久性的。
Opioid withdrawal can be associated to environmental cues through classical conditioning. Exposure to these cues can precipitate a state of conditioned withdrawal in abstinent subjects, and there are suggestions that conditioned withdrawal can perpetuate the addiction cycle in part by promoting the storage of memories. This review discusses evidence supporting the hypothesis that conditioned withdrawal facilitates memory consolidation by activating a neurocircuitry that involves the extended amygdala. Specifically, the central amygdala, the bed nucleus of the stria terminalis, and the nucleus accumbens shell interact functionally during withdrawal, mediate expression of conditioned responses, and are implicated in memory consolidation. From this perspective, the extended amygdala could be a neural pathway by which drug-seeking behaviour performed during a state of conditioned withdrawal is more likely to become habitual and persistent.