Hemodynamic impacts of various types of stenosis in the left coronary artery bifurcation: A patient-specific analysis
Hemodynamic impacts of various types of stenosis in the left coronary artery bifurcation: A patient-specific analysis
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DOI：
10.1016/j.ejmp.2013.02.001
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发表时间：
2013-09-01
影响因子：
3.4
通讯作者：
Jewkes, James
中科院分区：
文献类型：
--
作者：
Chaichana, Thanapong;Sun, Zhonghua;Jewkes, James
本研究基于对患者的具体分析，研究左冠状动脉分叉部不同类型冠状动脉狭窄的血流动力学变化。22例左冠状动脉疾病患者纳入本研究。所有累及左冠状动脉分叉的狭窄按部位分为四种类型：A)左回旋支(Lcx)和左前降支(LAD)，B)仅Lcx，C)仅左主干，D)仅LAD。应用计算流体力学(CFD)分析所有重建左冠状动脉的血流和壁切应力(WSS)的变化。结果显示，狭窄处血流速度和WSS显著增加。WSS在管腔狭窄70%处最高，为2.5~3.5Pa.这项研究表明，在左冠状动脉分叉狭窄超过50%的患者中，WSS在提供左冠状动脉分支冠状动脉粥样硬化程度方面发挥着重要作用。(C)2013年意大利医学协会。爱思唯尔有限公司出版。保留所有权利。
This study investigates the hemodynamic changes to various types of coronary stenosis in the left coronary artery bifurcation, based on a patient-specific analysis. Twenty two patients with left coronary artery disease were included in this study. All stenoses involving the left coronary artery bifurcation were classified into four types, according to their locations: A) left circumflex (LCx) and left anterior descending (LAD), B) LCx only, C) left main stem only, and D) LAD only. Computational fluid dynamics (CFD) was performed to analyze the flow and wall shear stress (WSS) changes in all reconstructed left coronary geometries. Our results showed that the flow velocity and WSS were significantly increased at stenotic locations. High WSS was found at >70% lumen stenosis, which ranged from 2.5 Pa to 3.5 Pa. This study demonstrates that in patients with more than 50% stenosis in the left coronary artery bifurcation, WSS plays an important role in providing information about the extent of coronary atherosclerosis in the left coronary artery branch. (C) 2013 Associazione Italians di Fisica Medica. Published by Elsevier Ltd. All rights reserved.