Responses to concurrent radiotherapy and hormone-therapy and outcome for large breast cancers in post-menopausal women
Responses to concurrent radiotherapy and hormone-therapy and outcome for large breast cancers in post-menopausal women
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DOI：
10.1016/j.radonc.2007.10.003
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发表时间：
2007-12-01
影响因子：
5.7
通讯作者：
Fourquet, Alain
中科院分区：
文献类型：
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作者：
Bollet, Marc A.;Kirova, Youlia M.;Fourquet, Alain
简介：本研究旨在评价绝经后妇女大面积乳腺癌同时行放射治疗（HT）和放疗（RT）的疗效和预后。材料和方法：对41例42例乳腺癌患者的乳腺淋巴结转移区行HT和RT治疗。对于30个肿瘤，随后进行乳房手术（腋窝未接受辐照时进行腋窝淋巴结清扫）。RT对肿瘤的平均剂量分别为50戈伊（48-66）和75戈伊（65-84），分别用于术前和排除性RT-HT。中位随访时间为64 months.Results：42个临床可评估的肿瘤（平均剂量为50戈伊后），9个肿瘤（21%）有完全临床反应，24个（57%）部分反应，9个（21%）稳定的疾病。74%的肿瘤可以进行保乳手术或单纯RT-HT。29例接受乳房手术的患者，病理完全缓解率为17%。在50戈伊剂量下，未发生高于2级的皮肤毒性。5年OS、RFS和局部控制率分别为85%、84%和97%。结论：RT-HT联合应用在临床和病理完全缓解方面显示了良好的疗效。它允许乳房保护，具有可接受的耐受性和良好的5年局部控制。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Introduction: This study aimed to evaluate responses and outcome of hormone-therapy (HT) and radiotherapy (RT) given concurrently for large breast cancers in post-menopausal women.Material and methods: Forty-two breast carcinomas in 41 women were treated with HIT and concurrent RT to the breast lymph node bearing areas. For 30 tumours this was followed by breast surgery (with axillary lymph node dissection when the axilla had not been irradiated). RT delivered a median dose to the tumour of 50 Gy (48-66) and 75 Gy (65-84) for, respectively, preoperative and exclusive RT-HT. Median follow-up was 64 months.Results: Out of 42 clinically assessable tumours (after a mean dose of 50 Gy), 9 tumours (21%) had complete clinical responses, 24 (57%) partial responses, 9 (21%) stable disease. Breast-conserving surgery or exclusive RT-HT was possible in 74% of tumours. For 29 patients who underwent breast surgery, the rate of pathological complete responses was 17%. At 50 Gy no skin toxicity higher than grade 2 occurred. Five year OS, RFS and local control were, respectively, 85%, 84% and 97%. Lymphoedema occurred in one patient.Conclusion: Concurrent association of RT-HT demonstrated good efficacy, both in terms of clinical and pathological complete responses. It allowed breast conservation with acceptable tolerance and good 5-year local control. (c) 2007 Elsevier Ireland Ltd. All rights reserved.