Cortisol and corticotrophin in burned patients.
Cortisol and corticotrophin in burned patients.
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烧伤患者的皮质醇和促肾上腺皮质激素。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
Arthur D. Mason
中科院分区：
文献类型：
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作者：
George M. Vaughan;Richard A. Becker;John P. Allen;John P. Allen;Cleon W. Goodwin;Basil A. Pruitt;Arthur D. Mason
在一项针对36名在火灾中烧伤的男性的研究中，根据连续的清晨样本，血浆皮质醇浓度与烧伤面积成比例升高。血浆促肾上腺皮质激素（ACTH）与烧伤面积无关，表明ACTH以外的因素有助于皮质醇升高。死亡者死亡前几天的皮质醇水平没有下降。在24小时的采样，烧伤患者表现出拟合皮质醇曲线平均值，烧伤面积成比例升高，节奏幅度显着低于未受伤的控制，和正常的峰值时间。代谢率、直肠温度和尿儿茶酚胺排泄量也随烧伤面积的增加而增加。虽然血浆皮质醇与代谢率和温度呈正相关，这似乎是由于这些变量与烧伤面积的共同关系。另一方面，尿儿茶酚胺值显着降低代谢率和温度的剩余方差后，占方差相关的烧伤面积。皮质醇似乎是不太突出的比儿茶酚胺作为一个可能的介质的升高产热。
In a study of 36 men burned in a fire, based on sequential early morning samples, plasma cortisol concentration was elevated in proportion to burn size. Plasma corticotrophin (ACTH) was not correlated with burn size, suggesting that factors other than ACTH contribute to the elevated cortisol. Cortisol levels did not fall on the days preceding death in nonsurvivors. During 24-hr sampling, burned patients exhibited a fitted cortisol curve mean that was elevated in proportion to burn size, a rhythm amplitude that was significantly less than that in uninjured controls, and a normal peak time. Metabolic rate, rectal temperature, and urinary catecholamine excretion were also elevated in proportion to burn size. Although plasma cortisol was positively correlated with metabolic rate and with temperature, this appeared to result from a common relationship of these variables with burn size. On the other hand, urinary catecholamine values significantly reduced the residual variance of metabolic rate and temperature after accounting for variance related to burn size. Cortisol appears to be less prominent than catecholamines as a possible mediator of the elevated thermogenesis.