FETAL AND INFANT ORIGINS OF CARDIOVASCULAR-DISEASE
FETAL AND INFANT ORIGINS OF CARDIOVASCULAR-DISEASE
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DOI：
10.1136/adc.68.6.797
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发表时间：
1993-06-01
影响因子：
5.2
通讯作者：
FALL, CHD
中科院分区：
文献类型：
--
作者：
BARKER, DJP;FALL, CHD
已知持续宫内生长迟缓的婴儿存在结构和代谢异常。例如，他们可能有一些器官的大小不成比例地减少，包括肝脏。他们的葡萄糖-胰岛素代谢异常，血清甘油三酯升高，血浆生长激素和皮质醇浓度升高。最近的一系列研究表明，结构和代谢的异常在婴儿中持续存在，并且他们在成年后患冠心病的风险增加。
Babies who sustain intrauterine growth retarda-tion are known to have structural and metabolic abnormalities. They may have, for example, disproportionate reduction in the size of some organs, including the liver. They have abnormal glucose-insulin metabolism,'raised serum triglycerides, 2 and high plasma growth hormone and cortisol3 concentrations. A recent series of studies has now shown that abnormalities of structure and metabolism persist in small for dates babiesand that they have an increased risk of coronary heart disease in adult life.