Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis
Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis
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DOI：
10.1507/endocrj.52.537
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发表时间：
2005-10-01
影响因子：
2
通讯作者：
Amino, N
中科院分区：
文献类型：
--
作者：
Noh, JY;Momotani, N;Amino, N
血清T-3/T-4比值是鉴别破坏性甲状腺毒症和Graves'甲状腺毒症的有用指标。然而，血清游离T-3（FT 3）与游离T-4（FT 4）比值的有用性存在争议。因此，我们系统地评估了这一比例的有用性，根据测量使用两个广泛使用的商业套件在两家医院。在Kuma医院检查了82名未经治疗的甲状腺毒症患者（48名Graves病患者和34名无痛性甲状腺炎患者），在Ito医院检查了218名患者（126名Graves病患者和92名无痛性甲状腺炎患者）和66名正常对照。在两家医院，Graves病患者的FT 3和FT 4值以及FT 3/FT 4比值均显著高于无痛性甲状腺炎患者，但观察到两种疾病之间存在相当大的重叠。制作两所医院Graves病和无痛性甲状腺炎患者的FT 3、FT 4值和FT 3/FT 4比值的受试者工作特征（ROC）曲线，计算曲线下面积（AUC）、Graves病和无痛性甲状腺炎的分界点、灵敏度和特异度。在两家医院，FT 3/FT 4比值的AUC和灵敏度均小于FT 3和FT 4。在伊藤医院接受治疗的患者然后根据他们的FT 4水平被分为4组（A：2.3类似于
The serum T-3 to T-4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T-3 (FT3) to free T-4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made using two widely available commercial kits in two hospitals. Eighty-two untreated patients with thyrotoxicosis (48 patients with Graves' disease and 34 patients with painless thyroiditis) were examined in Kuma Hospital, and 218 patients (126 with Graves' disease and 92 with painless thyroiditis) and 66 normal controls were examined in Ito Hospital. The FT3 and FT4 values, as well as the FT3/FT4 ratios, were significantly higher in the patients with Graves' disease than in those with painless thyroiditis in both hospitals, but considerable overlap between the two disorders was observed. Receiver operating characteristic (ROC) curves for the FT3 and FT4 values and the FT3/FT4 ratios of patients with Graves' disease and those with painless thyroiditis seen in both hospitals were prepared, and the area under the curves (AUC), the cut-off points for discriminating Graves' disease from painless thyroiditis, the sensitivity, and the specificity were calculated. AUC and sensitivity of the FT3/FT4 ratio were smaller than those of FT3 and FT4 in both hospitals. The patients treated at Ito hospital were then divided into 4 groups according to their FT4 levels (A: 2.3 similar to