Existing data sources for clinical epidemiology: Danish Cancer in Primary Care cohort.
Existing data sources for clinical epidemiology: Danish Cancer in Primary Care cohort.
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DOI：
10.2147/clep.s62855
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发表时间：
2014
影响因子：
3.9
通讯作者：
Vedsted P
中科院分区：
文献类型：
--
作者：
Jensen H;Tørring ML;Larsen MB;Vedsted P
在这篇文章中，我们描述了丹麦初级保健癌症(CAP)队列的设置、内容和可能性，以及到目前为止的一些关键发现。此外，我们还描述了该队列作为流行病学和卫生服务研究的国际资源的未来潜力。CAP队列包括2004-2005年、2007-2008年和2010年设立的三个丹麦子队列的信息，这些信息涉及18岁或以上的新诊断癌症患者。全科医生(GP)报告的和患者报告的数据来自六份问卷，生成了关于癌症延迟诊断的原因和后果的信息，这些数据还补充了关于死亡、移民、医疗保健利用、药物使用以及来自丹麦综合健康和行政登记的社会经济数据的完整信息。在移民、死亡、住院、用药和社会经济方面对队列进行跟踪，并定期更新数据。我们总共确认了22,169例确诊的癌症病例。在核实的病例中，17566例(79%)退回了填写好的全科医生问卷，8937例(40%)的受访者完成了患者问卷。有参与全科医生的患者与没有参与全科医生的患者在一年存活率、合并症或教育水平方面没有差异。然而，与没有参与的全科医生相比，有参与全科医生名单的患者更有可能是女性，更年轻，有更高的可支配收入，肿瘤有更多的区域或远程扩散，也更有可能患有乳腺癌，而不太可能患有前列腺癌。有反应的患者更有可能是年龄在45-74岁之间的女性，被诊断为乳腺癌或恶性黑色素瘤，并且有更高的一年存活率，更多的局部肿瘤，更高的教育背景和更高的可支配收入。该队列是流行病学和卫生服务研究的国际资源，数据可供明确定义和批准的合作研究使用。
In this paper, we describe the settings, content, and possibilities of the Danish Cancer in Primary Care (CaP) cohort as well as some of the key findings so far. Further, we describe the future potential of the cohort as an international resource for epidemiological and health services research studies. The CaP cohort comprises information from three Danish subcohorts set up in 2004–2005, 2007–2008, and 2010 on newly diagnosed cancer patients aged 18 years or older. General practitioner (GP)-reported and patient-reported data from six questionnaires generated information on causes and consequences of delayed diagnosis of cancer, and these data were supplemented with complete information on, eg, death, migration, health care utilization, medication use, and socioeconomic data from Denmark’s comprehensive health and administrative registers. The cohort is followed up in terms of emigration, death, hospitalization, medication, and socioeconomics, and data are updated regularly. In total, we identified 22,169 verified incident cancer cases. Completed GP questionnaires were returned for 17,566 (79%) of the verified cases, and patient questionnaires were completed by 8,937 (40%) respondents. Patients with participating GPs did not differ from patients with nonparticipating GPs in regard to one-year survival, comorbidity, or educational level. However, compared with nonparticipating GPs, patients listed with participating GPs were more likely to be women, younger, to have a higher disposable income, to have more regional or distant spread of tumors, were also more likely to have breast cancer, and were less likely to have prostate cancer. Responding patients were more likely to be women, aged 45–74 years, and diagnosed with breast cancer or malignant melanoma, and have higher one-year survival rates, more localized tumors, higher educational background, and higher disposable income. The cohort is an international resource for epidemiological and health service research, and data are accessible for well defined and approved collaborative studies.