Tick-virus interactions: Current understanding and future perspectives
Tick-virus interactions: Current understanding and future perspectives
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DOI：
10.1111/pim.12815
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发表时间：
2021-01-09
影响因子：
2.2
通讯作者：
Thangamani, Saravanan
中科院分区：
文献类型：
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作者：
Hart, Charles Edward;Thangamani, Saravanan
蜱是全球温带气候中虫媒病毒的主要载体。它们既是这些病原体传播给人类的载体，也是病毒森林循环的组成部分。了解蜱-病原体相互作用提供了有关这些病原体的自然维持的信息，并为制定对抗人类感染的对策提供了信息。在这篇综述中，我们讨论了目前可用的信息在更广泛的范围内一般蜱免疫蜱病毒相互作用。虽然蜱对几种病原体的免疫反应已被广泛研究，但对病毒感染的反应的工作很少。这在很大程度上是由于蜱传病毒的高致病性;这需要高遏制实验室或低致病性替代病毒。这使得大多数研究偏向于蜱传黄病毒。需要更多的工作，以充分了解蜱病毒相互作用的作用，在森林循环和传播的各种蜱传病毒。
Ticks are the primary vector of arboviruses in temperate climates worldwide. They are both the vector of these pathogens to humans and an integral component of the viral sylvatic cycle. Understanding the tick-pathogen interaction provides information about the natural maintenance of these pathogens and informs the development of countermeasures against human infection. In this review, we discuss currently available information on tick-viral interactions within the broader scope of general tick immunology. While the tick immune response to several pathogens has been studied extensively, minimal work centres on responses to viral infection. This is largely due to the high pathogenicity of tick-borne viruses; this necessitates high-containment laboratories or low-pathogenicity substitute viruses. This has biased most research towards tick-borne flaviviruses. More work is required to fully understand the role of tick-virus interaction in sylvatic cycling and transmission of diverse tick-borne viruses.