Glomerulonephritis in childhood
Glomerulonephritis in childhood
复制标题
儿童期肾小球肾炎
DOI：
10.1097/00008480-199704000-00007
复制
发表时间：
1997
影响因子：
3.6
通讯作者：
C. Pan
中科院分区：
文献类型：
--
作者：
C. Pan
更安全的肾活检技术增加了对儿童人群中各种形式的肾小球肾炎的认识。我们对它们的自然历史和进展有了更好的了解，现在我们知道，与IgA肾病和膜增生性肾小球肾炎等疾病相关的发病率很高。进行性肾脏疾病的病理生理学知识也有所增加，但缺乏具体的治疗方式，特别是儿童的治疗方式，仍是未来临床研究的领域。本文综述了儿童肾小球肾炎的四种类型：急性链球菌后肾小球肾炎、IgA肾病、Alport综合征和膜增生性肾小球肾炎。回顾了每一种肿瘤的临床和病理特征，并总结了目前有关其预后、遗传学或治疗方面的新进展的文献。
Safer renal biopsy techniques have led to increased recognition of the various forms of glomerulonephritis in the pediatric population. Our understanding of their natural history and progression has improved, and we now know that there is significant morbidity associated with diseases such as IgA nephropathy and membranoproliferative glomerulonephritis. Knowledge of the pathophysiology of progressive renal disease has also expanded, but specific treatment modalities, especially for children, are lacking and continue to be areas for future clinical research. This article reviews four types of glomerulonephritis that occur in childhood: acute poststreptococcal glomerulonephritis, IgA nephropathy, Alport's syndrome, and membranoproliferative glomerulonephritis. The clinical and pathologic features of each are reviewed, and the current literature covering new developments in their prognosis, genetics, or therapies are summarized.