Prospective longitudinal outcomes of quality of life after laparoscopic radical prostatectomy compared with retropubic radical prostatectomy.
Prospective longitudinal outcomes of quality of life after laparoscopic radical prostatectomy compared with retropubic radical prostatectomy.
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DOI：
10.1186/s12955-017-0835-1
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发表时间：
2018-01-05
影响因子：
3.6
通讯作者：
Ninomiya I
中科院分区：
文献类型：
--
作者：
Hashine K;Kakuda T;Iuchi S;Hosokawa T;Ninomiya I
关于日本患者腹腔镜根治性直肠癌切除术（LRP）后健康相关生活质量（HRQOL）的报道很少。本研究的目的是评估与耻骨后根治性膀胱切除术（RRP）相比，LRP后36个月期间HRQOL的变化。受试者为2011年至2012年期间接受LRP治疗的105例连续患者。在基线和术后1、3、6、12和36个月，使用国际前列腺症状评分（IPSS）、医学结局研究8项健康调查简表（SF-8）和扩展前列腺癌综合指数（EPIC）评价HRQOL。这些结果与2005年至2007年期间接受RRP治疗的107例连续患者的数据进行了比较。采用Mann-Whitney U检验和卡方检验对各时间点LRP和RRP进行比较。采用多元线性回归分析确定与EPIC尿域相关的独立因素。两组的IPSS变化相似。LRP组在基线时的SF-8心理健康总分更好，在术后1个月时的SF-8身体健康总分更好。在EPIC中，LRP后尿功能和麻烦更糟，但在12个月时有所改善，与RRP后无显著差异;然而，这些因素在LRP后36个月再次恶化。与RRP相比，LRP后36个月的尿失禁也更严重。在接受神经保留手术的患者中，两组在12个月和36个月时的尿功能和尿失禁相似且良好。两组的肠功能和麻烦，性功能和麻烦相似，从12个月到36个月没有变化。在多变量分析中，年龄和挽救性放疗是尿失禁（每天使用两个或更多个衬垫）的独立预测因素。手术操作不是尿失禁的独立因素，但尿失禁定义为使用一个或多个衬垫与手术操作相关。LRP术后36个月的尿功能和排尿困难均较RRP术后严重。年龄、挽救性放疗和手术与36个月后尿失禁相关。
There have been few reports on health-related quality of life (HRQOL) after laparoscopic radical prostatectomy (LRP) in Japanese patients. The aim of this study is to assess changes in HRQOL during 36 months after LRP compared with retropubic radical prostatectomy (RRP). The subjects were 105 consecutive patients treated with LRP between 2011 and 2012. HRQOL was evaluated using the International Prostate Symptom Score (IPSS), Medical Outcome Study 8-Items Short Form Health Survey (SF-8), and Expanded Prostate Cancer Index Composite (EPIC) at baseline and 1, 3, 6, 12 and 36 months after surgery. These results were compared with data for 107 consecutive patients treated with RRP between 2005 and 2007. The comparison between LRP and RRP was examined at every time point by Mann-Whitney U-test and chi-square test. Multiple linear regression analysis was used to identify independent factors related to the urinary domain in EPIC. The IPSS change was similar in both groups. The LRP group had a better SF-8 mental component summary score at baseline and a better SF-8 physical component summary score at 1 month after surgery. In EPIC, urinary function and bother were worse after LRP, but improved at 12 months and did not differ significantly from those after RRP; however, these factors then worsened again at 36 months after LRP. Urinary incontinence was also worse at 36 months after LRP, compared to RRP. In patients treated with nerve-sparing surgery, urinary function and urinary incontinence were similar and good at 12 and 36 months in both groups. Bowel function and bother, and sexual function and bother were similar in both groups and showed no changes from 12 to 36 months. Age and salvage radiotherapy were independent predictors of incontinence (daily use of two or more pads) in multivariate analysis. Surgical procedure was not an independent factor for incontinence, but incontinence defined as use of one pad or more was associated with the surgical procedure. Urinary function and bother at 36 months were worse after LRP than after RRP. Age, salvage radiotherapy and surgical procedure were associated with urinary incontinence after 36 months.
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影响因子：
23.4
作者：
Haglind, Eva;Carlsson, Stefan;Steineck, Gunnar
通讯作者：
Steineck, Gunnar
DOI：
10.1056/nejmoa1209978
发表时间：
2013-01-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Resnick MJ;Koyama T;Fan KH;Albertsen PC;Goodman M;Hamilton AS;Hoffman RM;Potosky AL;Stanford JL;Stroup AM;Van Horn RL;Penson DF
通讯作者：
Penson DF
影响因子：
23.4
作者：
Porpiglia, Francesco;Morra, Ivano;Fiori, Cristian
通讯作者：
Fiori, Cristian
影响因子：
6.6
作者：
Jacobsen, Niels-Erik B.;Moore, Katherine N.;Voaklander, Donald
通讯作者：
Voaklander, Donald
影响因子：
2.6
作者：
Namiki, Shunichi;Kaiho, Yasuhiro;Arai, Yoichi
通讯作者：
Arai, Yoichi