Effects of Aging on the Human Brain: A Proton and Phosphorus MR Spectroscopy Study at 3T
Effects of Aging on the Human Brain: A Proton and Phosphorus MR Spectroscopy Study at 3T
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DOI：
10.1111/jon.12514
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发表时间：
2018-07-01
影响因子：
2.4
通讯作者：
Ding, Xiao-Qi
中科院分区：
文献类型：
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作者：
Schmitz, Birte;Wang, Xin;Ding, Xiao-Qi
背景与目的研究累积性衰老对人脑神经代谢的影响，并收集参考数据集。方法对54例年龄在22 ~ 73岁的健康志愿者进行全脑H-1-MR联合P-31-MRS 3T研究。测定脑内n -乙酰天冬氨酸（NAA）、总胆碱（tCho）、总肌酸（tCr）以及磷酸肌酸（PCr）、5-三磷酸腺苷（ATP）、磷酸单酯（PME）、磷酸二酯（PDE）和无机磷酸盐（Pi）的代谢产物浓度。脑灰质（FVGM）、白质（FVWM）和总组织（FVTB, GM+WM）的分数体积也被估计。结果随着年龄的增长，NAA、ATP、PME、FVTB、FVGM呈线性下降，tCho、FVWM呈线性上升。FVGM与NAA、ATP、PME和Pi的整体浓度呈正相关。结论衰老人脑中与年龄相关的累积代谢变化与神经元代谢活性和密度降低有关，表现为NAA降低，ATP降低导致线粒体活性降低，PME降低导致膜合成减少。这些变化与年龄相关的神经元体积减少有关。全局NAA和ATP可作为人脑衰老监测的替代生物标志物。
BACKGROUND AND PURPOSETo investigate accumulative aging effects on neurometabolism in human brain and to collect a reference dataset.METHODSFifty-four healthy volunteers aged evenly between 22 and 73 years were studied using whole-brain H-1-MR spectroscopic imaging in combination with P-31-MRS at 3T. Global metabolite concentrations of brain N-acetylaspartate (NAA), total choline (tCho), and total creatine (tCr), as well as phosphocreatine (PCr), adenosine-5-triphosphate (ATP), phosphomonoesters (PME), phosphodiesters (PDE), and inorganic phosphate (Pi) were determined. Fractional volumes of brain gray matter (FVGM), white matter (FVWM), and total tissue (FVTB, GM+WM) were also estimated.RESULTSWith age, NAA, ATP, and PME, as well as FVTB and FVGM decreased and tCho and FVWM increased linearly. Positive correlations were found between FVGM and global concentrations of NAA, ATP, PME, and Pi.CONCLUSIONAge-related accumulative metabolic changes in aging human brain correlated with reduced neuronal metabolic activity and density, reflected by decreased NAA, reduced mitochondrial activity by decreased ATP, and reduced membrane synthesis by decreased PME. These changes are associated with age-related decrease of neuronal volume. Global NAA and ATP might be used as surrogate biomarker for monitoring aging in human brain.