Antral recirculation in the stomach during gastric mixing
Antral recirculation in the stomach during gastric mixing
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DOI：
10.1152/ajpgi.00350.2012
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发表时间：
2013-03-01
影响因子：
4.5
通讯作者：
Yamaguchi, Takami
中科院分区：
文献类型：
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作者：
Imai, Yohsuke;Kobayashi, Ikuma;Yamaguchi, Takami
[10]张文忠，张文忠.胃混合时的胃窦再循环。美国生理学杂志胃肠和肝脏生理学304：G536-G542，2013年。首次发布于2013年12月28日; doi：10.1152/ajpgi.00350.2012。-我们调查流动在胃混合过程中使用的数值模拟与解剖学上逼真的几何形状和自由表面流动建模。由于在蠕动收缩期间较大曲率和较小曲率之间的动量差，在胃窦中产生时间平均再循环，其中逆行流远离幽门并且补偿流沿着较大曲率朝向幽门。远端胃内容物通过胃窦再循环的前向流被持续输送到远端胃窦，然后被后向的后向流混合。因此，胃窦再循环内的内容物混合良好，与初始位置无关，而再循环外的内容物混合不良。自由表面建模使我们能够分析姿势对胃混合的影响。在直立、俯卧和右侧卧位，大部分胃窦充满内容物，内容物通过胃窦再循环充分混合。相反，在仰卧位和左侧卧位，大部分内容物位于胃窦再循环外，这导致混合不良。胃的弯曲、扭曲的形状基本上支持流体机械术语中的胃混合。
Imai Y, Kobayashi I, Ishida S, Ishikawa T, Buist M, Yamaguchi T. Antral recirculation in the stomach during gastric mixing. Am J Physiol Gastrointest Liver Physiol 304: G536-G542, 2013. First published December 28, 2013; doi:10.1152/ajpgi.00350.2012.-We investigate flow in the stomach during gastric mixing using a numerical simulation with an anatomically realistic geometry and free-surface flow modeling. Because of momentum differences between greater and lesser curvatures during peristaltic contractions, time-averaged recirculation is generated in the antrum, with retropulsive flow away from the pylorus and compensation flow along the greater curvature toward the pylorus. Gastric content in the distal stomach is continuously transported to the distal antrum by the forward flow of antral recirculation, and it is then mixed by the backward retropulsive flow. Hence, the content inside the antral recirculation is well mixed independently of initial location, whereas the content outside the recirculation is poorly mixed. Free-surface modeling enables us to analyze the effects of posture on gastric mixing. In the upright, prone, and right lateral positions, most of the antrum is filled with content, and the content is well mixed by antral recirculation. In contrast, in the supine and left lateral positions, most of the content is located outside antral recirculation, which results in poor mixing. The curved, twisted shape of the stomach substantially supports gastric mixing in fluid mechanical terms.