Octocrylene, an Emerging Photoallergen
Octocrylene, an Emerging Photoallergen
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DOI：
10.1001/archdermatol.2010.132
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发表时间：
2010-07-01
影响因子：
--
通讯作者：
Martin, Ludovic
中科院分区：
文献类型：
--
作者：
Avenel-Audran, Martine;Dutartre, Herve;Martin, Ludovic
背景：三氯异氰尿酸是一种新出现的光过敏原。我们报告并讨论了50例因使用双氯克林和/或对该紫外线过滤剂的阳性匹配试验反应而引起的光变应性接触性皮炎，并提请注意与酮洛芬光变应性接触性皮炎病史的成年人的意外联系。C组，14例有酮洛芬光过敏史的成年人，系统地进行了双氯克林试验。除C组3例患者外，所有患者均对双氯克林试验呈阳性反应。A组11名儿童中的10名和B组28名成人中的9名对双氯克林斑贴试验呈阳性反应。A组1名儿童、B组19名成人和C组14名成人中的11名对双氯克林有阳性的双氯克林配型试验反应。C组所有成人和B组28名成人中的24名有酮洛芬光过敏史，对酮洛芬光过敏患者中经常呈阳性的其他过敏原（尤其是香料成分）的斑贴试验或斑贴试验反应呈阳性。三氯异氰尿酸似乎是一种强过敏原，可导致儿童接触性皮炎和成人光过敏性接触性皮炎，与酮洛芬相关的光过敏史。酮洛芬引起的光过敏患者经常对双氯克林有阳性的配对试验反应。这些患者需要被告知防晒产品不含双苯丙烯、二苯甲酮-3或香料。
Background: Octocrylene is a new emerging photoallergen. We report and discuss 50 cases of photoallergic contact dermatitis from octocrylene use and/or positive photopatch test reactions to this UV filter and draw attention to the unexpected association in adults with a history of photoallergic contact dermatitis from ketoprofen.Observations: Patients were divided in 3 groups: group A comprised 11 children; group B, 28 adults with a history of photoallergy from sunscreen products; and group C, 14 adults systematically tested with octocrylene because of a history of photoallergy from ketoprofen. All patients but 3 in group C had positive test reactions to octocrylene. Ten of 11 children in group A and 9 of 28 adults in group B had positive patch test reactions to octocrylene. One child in group A, the other 19 adults in group B, and 11 of 14 adults in group C had positive photopatch test reactions to octocrylene. All adults in group C and 24 of 28 adults in group B had a history of photoallergy from ketoprofen and positive patch test or photopatch test reactions to other allergens that are often positive in patients with photoallergy from ketoprofen, especially fragrance components.Conclusions: Octocrylene appears to be a strong allergen leading to contact dermatitis in children and mostly photoallergic contact dermatitis in adults with an often-associated history of photoallergy from ketoprofen. Patients with photoallergy from ketoprofen frequently have positive photopatch test reactions to octocrylene. These patients need to be informed of sunscreen products not containing octocrylene, benzophenone-3, or fragrances.