Postnatal development of prefrontal inhibitory circuits and the pathophysiology of cognitive dysfunction in schizophrenia
Postnatal development of prefrontal inhibitory circuits and the pathophysiology of cognitive dysfunction in schizophrenia
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DOI：
10.1196/annals.1308.008
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Erickson, S
中科院分区：
文献类型：
--
作者：
Lewis, DA;Cruz, D;Erickson, S
精神分裂症的临床特征在青春期后期或成年早期的典型表现表明，青春期相关的神经发育事件可能有助于这种疾病的病理生理学。在这里，GABA介导的抑制在背外侧前额叶皮层（DLPFC）在调节工作记忆，一个核心的认知过程，成熟晚，这是精神分裂症的干扰中发挥的作用，进行审查。总结了最近的研究表明：（1）猴DLPFC中GABA神经传递的某些突触前和突触后标记物在青春期表现出显著的变化，（2）精神分裂症受试者的DLPFC中这些相同的标记物发生了显著改变。这些研究结果的治疗和预防策略的影响进行了讨论。
The typical appearance of the clinical features of schizophrenia during late adolescence or early adulthood suggests that adolescence-related neurodevelopmental events may contribute to the pathophysiology of this disorder. Here the role that GABA-mediated inhibition in the dorsal lateral prefrontal cortex (DLPFC) plays in regulating working memory, a core cognitive process that matures late and that is disturbed in schizophrenia, is reviewed. Recent studies are summarized that demonstrate (1) that certain pre- and postsynaptic markers of GABA neurotransmission in the monkey DLPFC exhibit striking changes during adolescence, and (2) that these same markers are markedly altered in the DLPFC of subjects with schizophrenia. The implications of these findings for treatment and prevention strategies are discussed.