The integrin adhesome network at a glance.
The integrin adhesome network at a glance.
复制标题
DOI：
10.1242/jcs.192054
复制
发表时间：
2016-11-15
影响因子：
4
通讯作者：
Humphries MJ
中科院分区：
文献类型：
--
作者：
Horton ER;Humphries JD;James J;Jones MC;Askari JA;Humphries MJ
粘附连接是整合素受体桥接细胞内细胞骨架和细胞外基质网络的位点。整合素和细胞骨架之间的连接是由动态整合素粘附复合物（IAC）介导的，其成分可转导化学和机械信号以控制多种细胞功能。在这篇《细胞科学概览》文章和随附的海报中，我们将共识粘附体（一组在分离的 IAC 蛋白质组中最常见的 60 种蛋白质）与文献策划的粘附体（通过对 IAC 本地化蛋白质的学术分析组装而成的理论网络）进行了整合。由此产生的 IAC 网络由四个广泛的信号传导轴和肌动蛋白桥接轴组成，为未来研究健康和疾病中粘附连接的调节和功能提供了一个平台。摘要：我们对整合素粘附体网络进行了新的描述，该网络将实验衍生的 IAC 蛋白质组与文献策划的粘附体相结合，以弥合这两种资源之间的知识差距。
The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between integrins and the cytoskeleton is mediated by a dynamic integrin adhesion complex (IAC), the components of which transduce chemical and mechanical signals to control a multitude of cellular functions. In this Cell Science at a Glance article and the accompanying poster, we integrate the consensus adhesome, a set of 60 proteins that have been most commonly identified in isolated IAC proteomes, with the literature-curated adhesome, a theoretical network that has been assembled through scholarly analysis of proteins that localise to IACs. The resulting IAC network, which comprises four broad signalling and actin-bridging axes, provides a platform for future studies of the regulation and function of the adhesion nexus in health and disease. Summary: We have generated a new depiction of the integrin adhesome network that integrates experimentally derived IAC proteomes with the literature-curated adhesome to bridge the knowledge gap between these two resources.
登录
查看更多内容
DOI：
10.1083/jcb.201508080
发表时间：
2016-02-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Horton ER;Humphries JD;Stutchbury B;Jacquemet G;Ballestrem C;Barry ST;Humphries MJ
通讯作者：
Humphries MJ
影响因子：
2.5
作者：
Koester, Johannes;Zamir, Eli;Rahmann, Sven
通讯作者：
Rahmann, Sven
影响因子：
21.3
作者：
Alanko J;Mai A;Jacquemet G;Schauer K;Kaukonen R;Saari M;Goud B;Ivaska J
通讯作者：
Ivaska J
影响因子：
7.2
作者：
Geiger B;Yamada KM
通讯作者：
Yamada KM
影响因子：
7.3
作者：
Humphries JD;Byron A;Bass MD;Craig SE;Pinney JW;Knight D;Humphries MJ
通讯作者：
Humphries MJ