Morphology and morphometry of human chronic spinal cord injury using diffusion tensor imaging and fuzzy logic
Morphology and morphometry of human chronic spinal cord injury using diffusion tensor imaging and fuzzy logic
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DOI：
10.1007/s10439-007-9415-6
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发表时间：
2008-02-01
影响因子：
3.8
通讯作者：
Schmit, Brian D.
中科院分区：
文献类型：
--
作者：
Ellingson, Benjamin M.;Ulmer, John L.;Schmit, Brian D.
对四名患有慢性脊髓损伤（SCI）的人类受试者的损伤部位的嘴部区域和四名神经系统完整的受试者的同等区域进行了弥散张量成像（DTI）。测量并比较受试者之间的表观扩散系数。使用模糊逻辑组织分类算法来分割灰质和白质区域以进行形态测量分析，包括比较灰质和白质的横截面积以及额叶和矢状直径。结果表明，慢性 SCI 患者上颈段的纵向和横向扩散率普遍下降。此外，在 SCI 受试者中观察到整个脊髓横截面积减少，这与脊髓严重萎缩一致。这些观察结果对于追踪 SCI 从急性阶段到慢性阶段的进展具有重要意义。我们得出的结论是，具有模糊逻辑组织分类的 DTI 具有监测 SCI 患者脊髓形态变化的潜力。
Diffusion tensor imaging (DTI) was performed on regions rostral to the injury site in four human subjects with chronic spinal cord injury (SCI) and equivalent regions in four neurologically intact subjects. Apparent diffusion coefficients were measured and compared between subjects. A fuzzy logic tissue classification algorithm was used to segment gray and white matter regions for morphometric analysis, including comparisons of cross-sectional areas of gray and white matter along with frontal and sagittal diameters. Results indicated a general decrease in both longitudinal and transverse diffusivity in the upper cervical segments of subjects with chronic SCI. Further, a decrease in the cross-sectional area of the entire spinal cord was observed in subjects with SCI, consistent with severe atrophy of the spinal cord. These observations have implications in tracking the progression of SCI from the acute to the chronic stages. We conclude that DTI with fuzzy logic tissue classification has potential for monitoring morphological changes in the spinal cord in people with SCI.