Cyclin D1 overexpression as a prognostic factor in patients with esophageal carcinoma
Cyclin D1 overexpression as a prognostic factor in patients with esophageal carcinoma
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DOI：
10.1002/jso.1152
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发表时间：
2001-11-01
影响因子：
2.5
通讯作者：
Miyashita, M
中科院分区：
文献类型：
--
作者：
Nagasawa, S;Onda, M;Miyashita, M
背景和目标：已知 Cyclin D1 在细胞周期的 GUS 检查点中发挥重要作用。我们研究了cyclin D1过表达与临床特征之间的相关性，以阐明其在食管癌患者中的意义。方法：从1991年到1998年，对86例接受食管切除术的食管癌患者进行了cyclin D1的研究。免疫组化法检测cyclin D1过表达。结果：86例中23例（26.7%）出现cyclin D1过表达。 cyclin D1 的过表达与淋巴结转移 (P = 0.0083) 和淋巴管侵袭 (P = 0.018) 相关。 Cyclin D1 过度表达可能表明对化疗产生耐药性。 cyclin D1过表达患者的生存率显着低于未过表达患者（P = 0.013）。多变量分析显示cyclin D1过表达是食管癌患者的重要预后因素。结论：cyclin D1表达的免疫组织化学检查可以在单变量和多变量分析中提供重要的预后信息，并且对于确定食管癌的治疗策略可能是必要的。 (C) 2001 Wiley-Liss, Inc.
Background and Objectives: Cyclin D1 is known to play important roles in the GUS check-point of the cell cycle. We investigated the correlation between cyclin D1 overexpression and clinical characteristics to clarify its significance in patients with esophageal cancer.Methods: From 1991 to 1998, cyclin D1 was investigated in esophageal cancers from 86 patients who underwent esophagectomy. Overexpression of cyclin D1 was demonstrated using an immunohistochemical method.Results: Overexpression of cyclin D1 was found in 23 (26.7%) of 86 cases. Overexpression of cyclin D1 correlated with lymph node metastasis (P = 0.0083) and lymphatic vessel invasion (P = 0.018). Cyclin D1 overexpression may indicate resistance to chemotherapy. The patients with cyclin D1 overexpression had a significantly lower survival rate than those without overexpression (P = 0.013). The multivariate analysis revealed cyclin D1 overexpression to be an important prognostic factor in patients with esophageal cancer.Conclusions: Immunohistochemical examination of cyclin D1 expression may provide important prognostic information in univariate and multivariate analysis and may be necessary for determining therapeutic strategies for esophageal cancer. (C) 2001 Wiley-Liss, Inc.